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    CIP8 COP1-interacting protein 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836616, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CIP8
    Official Full Name
    COP1-interacting protein 8
    Primary source
    TAIR:AT5G64920
    Locus tag
    AT5G64920
    See related
    Araport:AT5G64920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COP1-interacting protein 8; COP1-INTERACTING PROTEIN CIP8; MXK3.15; MXK3_15
    Summary
    Encodes a RING-H2 protein that interacts with the RING finger domain of COP1. CIP8 exhibits a strong interaction with the E2 ubiquitin conjugating enzyme AtUBC8 through its N-terminal domain and promotes ubiquitination in an E2-dependent fashion in vitro. It is possible that the AtUBC8-CIP8 module might interact with COP1 in vivo, thereby participating in proteasome-mediated degradation of HY5.
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    Genomic context

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    See CIP8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (25943888..25945442, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene precursor of peptide 1 Neighboring gene elicitor peptide 3 precursor Neighboring gene Serine/Threonine-kinase Neighboring gene ncRNA Neighboring gene CPR5 protein Neighboring gene ABC2 homolog 13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein. Torii KU, et al. J Biol Chem, 1999 Sep 24. PMID 10488108
    2. LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1. Seo HS, et al. Nature, 2003 Jun 26. PMID 12827204
    3. Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Hardtke CS, et al. Plant J, 2002 May. PMID 12028569
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125891.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    COP1-interacting protein 8
    NP_201297.1
    • COP1-interacting protein 8 (CIP8); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT5G01980.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25943888..25945442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125891.3 → NP_201297.1  COP1-interacting protein 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SPL2
      UniProtKB/TrEMBL
      A0A178UJC6, A0A384L1Y1, A0A654GF77, A6XFC3
      Conserved Domains (3) summary
      cd00162
      Location:257 → 297
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      pfam14369
      Location:14 → 46
      zinc_ribbon_9; zinc-ribbon
      cl17238
      Location:257 → 298
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SPL2.1

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