PROPEP1 precursor of peptide 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PROPEP1
Official Full Name: precursor of peptide 1
Primary source: TAIR:AT5G64900
Locus tag: AT5G64900
See related: Araport:AT5G64900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PEPTIDE 1; ATPEP1; MXK3.13; MXK3_13; PEP1; PEPTIDE 1; precursor of peptide 1
Summary: Encodes a putative 92-aa protein that is the precursor of AtPep1, a 23-aa peptide which activates transcription of the defensive gene defensin (PDF1.2) and activates the synthesis of H2O2, both being components of the innate immune response.
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Genomic context

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See PROPEP1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (25937078..25938176)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.
Title: Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.
this study demonstrates that upon damage, both at the tissue and single-cell levels, the cysteine protease METACASPASE4 (MC4) is instantly and spatiotemporally activated by binding high levels of Ca(2+) and is necessary and sufficient for Pep1 maturation.
Title: Damage on plants activates Ca(2+)-dependent metacaspases for release of immunomodulatory peptides.
Interaction In AtPep1-PEPR1 Complex In Arabidopsis thaliana
Title: Mechanistic Basis Of Peptide-Protein Interaction In AtPep1-PEPR1 Complex In Arabidopsis thaliana.
these results indicate an additional level of regulation besides receptor abundance for the RbohD/RbohF-dependent production of AtPep-elicited reactive oxygen species.
Title: The anticipation of danger: microbe-associated molecular pattern perception enhances AtPep-triggered oxidative burst.
Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2.
Title: Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2.
AtPep1 is a 23-aa peptide derived from AtPep1 precursor gene PROPEP1, which activates transcription of the defensive gene defensin (PDF1.2). [AtPep1]
Title: An endogenous peptide signal in Arabidopsis activates components of the innate immune response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_125888.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ethylene	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: precursor of peptide 1

NP_569001.1

precursor of peptide 1 (PROPEP1); BEST Arabidopsis thaliana protein match is: elicitor peptide 2 precursor (TAIR:AT5G64890.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

25937078..25938176

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125888.4 → NP_569001.1 precursor of peptide 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_569001.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LCK9, Q9LV87

UniProtKB/TrEMBL

A0A178UGP1, A0A5S9YH28

Conserved Domains (1) summary

pfam17232
Location:1 → 88

DUF5306; Family of unknown function (DUF5306)