BAM1 Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BAM1
Official Full Name: Leucine-rich receptor-like protein kinase family protein
Primary source: TAIR:AT5G65700
Locus tag: AT5G65700
See related: Araport:AT5G65700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BARELY ANY MERISTEM 1; MPA24.5; MPA24_5
Summary: Encodes a CLAVATA1-related receptor kinase-like protein required for both shoot and flower meristem function. Very similar to BAM2,with more than 85% a.a. identity. It has a broad expression pattern and is involved in vascular strand development in the leaf, control of leaf shape, size and symmetry, male gametophyte development and ovule specification and function. Anthers of double mutants (bam1bam2) appeared abnormal at a very early stage and lack the endothecium, middle, and tapetum layers. Further analyses revealed that cells interior to the epidermis (in anther tissue) acquire some characteristics of pollen mother cells (PMCs), suggesting defects in cell fate specification. The pollen mother-like cells degenerate before the completion of meiosis, suggesting that these cells are defective. In addition, the BAM1 expression pattern supports both an early role in promoting somatic cell fates and a subsequent function in the PMCs.
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Genomic context

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See BAM1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (26281642..26285413)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLE3 and its homologs share overlapping functions in the modulation of lateral root formation through CLV1 and BAM1 in Arabidopsis thaliana.
Title: CLE3 and its homologs share overlapping functions in the modulation of lateral root formation through CLV1 and BAM1 in Arabidopsis thaliana.
Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.
Title: Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.
BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots.
Title: BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots.
Driven by a constitutive CaMV 35S promoter, a truncated BAM protein (BAMDelta) that lacks either the signal peptide or the cytoplasmic kinase domain could cause defective shoot apical meristem maintenance, which phenotypically resembled the triple bam mutant. Such a dominant-negative effect could also be achieved when the same transgene was driven by the native AtBAM1 promoter.
Title: Truncated BAM receptors interfere the apical meristematic activity in a dominant negative manner when ectopically expressed in Arabidopsis.
BAM1 is an element required for the cell-to-cell spread of RNAi.
Title: A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi.
Sodium nitroprusside, which releases NO, did not affect BAM1 activity. After treatment of recombinant BAM1 with GSNO, BAM1 was largely unaffected. A BAM1 mutant resembling BAM3 was sensitive to GSNO inhibition.
Title: Glutathionylation Inhibits the Catalytic Activity of Arabidopsis β-Amylase3 but Not That of Paralog β-Amylase1.
Study demonstrate that abscisic acid controls the activity of BAM1 and AMY3 in leaves under osmotic stress through the AREB/ABF-SnRK2 kinase-signaling pathway. We propose that differential regulation and isoform subfunctionalization define starch-adaptive plasticity, ensuring an optimal carbon supply for continued growth under an ever-changing environment.
Title: Regulation of Leaf Starch Degradation by Abscisic Acid Is Important for Osmotic Stress Tolerance in Plants.
These findings suggest that the BAM1 and RPK2 receptors constitute a signaling pathway that modulates cell proliferation in the root meristem and that related molecules are employed in root and shoot meristems.
Title: BAM 1 and RECEPTOR-LIKE PROTEIN KINASE 2 constitute a signaling pathway and modulate CLE peptide-triggered growth inhibition in Arabidopsis root.
Amino acid composition of BAM1 and BAM3 orthologs reflected differences that are consistent with known adaptations of proteins from heat- and cold-adapted organisms, suggesting that the day- and night-active enzymes have undergone thermal adaptation.
Title: β-Amylase1 and β-amylase3 are plastidic starch hydrolases in Arabidopsis That Seem to Be Adapted for Different Thermal, pH, and stress conditions.
BAM1 directly interacts with the small peptide ligand CLE9.
Title: Biochemical mapping of a ligand-binding domain within Arabidopsis BAM1 reveals diversified ligand recognition mechanisms of plant LRR-RKs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203695.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anther development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within floral organ development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gametophyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within microsporocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of meristem growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of meristem structural organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Leucine-rich receptor-like protein kinase family protein

NP_001190624.1

BARELY ANY MERISTEM 1 (BAM1); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich receptor-like protein kinase family protein (TAIR:AT3G49670.1).

NP_201371.1

BARELY ANY MERISTEM 1 (BAM1); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: in 9 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich receptor-like protein kinase family protein (TAIR:AT3G49670.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26281642..26285413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125967.5 → NP_201371.1 Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201371.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49545

UniProtKB/TrEMBL

A0A178UM62, A0A5S9YJF0

Conserved Domains (2) summary

PLN00113
Location:25 → 965

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:71 → 94

LRR_RI; leucine-rich repeat [structural motif]
NM_001203695.1 → NP_001190624.1 Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190624.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49545

UniProtKB/TrEMBL

A0A178UM62, A0A5S9YJF0

Conserved Domains (2) summary

PLN00113
Location:25 → 965

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:71 → 94

LRR_RI; leucine-rich repeat [structural motif]