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    ABA1 zeaxanthin epoxidase (ZEP) (ABA1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836838, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABA1
    Official Full Name
    zeaxanthin epoxidase (ZEP) (ABA1)
    Primary source
    TAIR:AT5G67030
    Locus tag
    AT5G67030
    See related
    Araport:AT5G67030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA DEFICIENT 1; ARABIDOPSIS THALIANA ABA DEFICIENT 1; ARABIDOPSIS THALIANA ZEAXANTHIN EPOXIDASE; ATABA1; ATZEP; IBS3; IMPAIRED IN BABA-INDUCED STERILITY 3; K8A10.10; K8A10_10; LOS6; LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6; NON-PHOTOCHEMICAL QUENCHING 2; NPQ2; ZEAXANTHIN EPOXIDASE; ZEP
    Summary
    Encodes a single copy zeaxanthin epoxidase gene that functions in first step of the biosynthesis of the abiotic stress hormone abscisic acid (ABA). Mutants in this gene are unable to express female sterility in response to beta-aminobutyric acid, as wild type plants do.
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    Genomic context

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    See ABA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (26753469..26757402, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene uncharacterized protein Neighboring gene F-box protein, putative (DUF295) Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Singlet oxygen triggers chloroplast rupture and cell death in the zeaxanthin epoxidase defective mutant aba1 of Arabidopsis thaliana under high light stress. Sánchez-Corrionero Á, et al. J Plant Physiol, 2017 Sep. PMID 28709027
    2. Arabidopsis mutants define a central role for the xanthophyll cycle in the regulation of photosynthetic energy conversion. Niyogi KK, et al. Plant Cell, 1998 Jul. PMID 9668132, Free PMC Article
    3. A mutational analysis of the ABA1 gene of Arabidopsis thaliana highlights the involvement of ABA in vegetative development. Barrero JM, et al. J Exp Bot, 2005 Aug. PMID 15983017
    4. The ABA1 gene and carotenoid biosynthesis are required for late skotomorphogenic growth in Arabidopsis thaliana. Barrero JM, et al. Plant Cell Environ, 2008 Feb. PMID 17996011
    5. Overexpression of Arabidopsis ZEP enhances tolerance to osmotic stress. Park HY, et al. Biochem Biophys Res Commun, 2008 Oct 10. PMID 18680727

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZEP role in the carotenoid degradation in maturing seed.ZEP is expressed in the haplotype specific fashion during late seed development.
      Title: ZEAXANTHIN EPOXIDASE Activity Potentiates Carotenoid Degradation in Maturing Seed.
    2. aba1 may serve as an alternative model to other (1)singlet oxygen (O2-)overproducing mutants of Arabidopsis for investigating (1)O2-mediated cell death.
      Title: Singlet oxygen triggers chloroplast rupture and cell death in the zeaxanthin epoxidase defective mutant aba1 of Arabidopsis thaliana under high light stress.
    3. These data support a tissue- and stress-specific accumulation of the ZEP protein in accordance with its different functions in abscissic acid biosynthesis and the xanthophyll cycle.
      Title: Tissue-specific accumulation and regulation of zeaxanthin epoxidase in Arabidopsis reflect the multiple functions of the enzyme in plastids.
    4. ABA1 is required for skotomorphogenic growth, and beta-carotene-derived xanthophylls are putative regulators of skotomorphogenesis.
      Title: The ABA1 gene and carotenoid biosynthesis are required for late skotomorphogenic growth in Arabidopsis thaliana.
    5. AtZEP plays important roles in response to osmotic stress.
      Title: Overexpression of Arabidopsis ZEP enhances tolerance to osmotic stress.
    6. A description of the molecular and phenotypic characterization of a large series of mutant alleles of the ABA1 gene, which cause different degrees of ABA deficiency, four of them previously isolated and the remaining five novel, is presented.
      Title: A mutational analysis of the ABA1 gene of Arabidopsis thaliana highlights the involvement of ABA in vegetative development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_126103.2
    NM_180954.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zeaxanthin epoxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscisic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within abscisic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within xanthophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    zeaxanthin epoxidase (ZEP) (ABA1)
    NP_201504.2
    • ABA DEFICIENT 1 (ABA1); FUNCTIONS IN: zeaxanthin epoxidase activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zeaxanthin epoxidase (InterPro:IPR017079), Monooxygenase, FAD-binding (InterPro:IPR002938); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase family protein (TAIR:AT2G35660.1); Has 6741 Blast hits to 6737 proteins in 1083 species: Archae - 12; Bacteria - 3697; Metazoa - 0; Fungi - 1597; Plants - 576; Viruses - 0; Other Eukaryotes - 859 (source: NCBI BLink).
    NP_851285.1
    • ABA DEFICIENT 1 (ABA1); FUNCTIONS IN: zeaxanthin epoxidase activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SMAD/FHA domain (InterPro:IPR008984), Zeaxanthin epoxidase (InterPro:IPR017079), Monooxygenase, FAD-binding (InterPro:IPR002938), Forkhead-associated (FHA) domain (InterPro:IPR000253); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase family protein (TAIR:AT2G35660.1); Has 6841 Blast hits to 6837 proteins in 1107 species: Archae - 14; Bacteria - 3761; Metazoa - 2; Fungi - 1599; Plants - 605; Viruses - 0; Other Eukaryotes - 860 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26753469..26757402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180954.3 → NP_851285.1  zeaxanthin epoxidase (ZEP) (ABA1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851285.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K278, Q8RXE6, Q9FDX0, Q9FGC7, Q9FS21, Q9LDB9
      UniProtKB/TrEMBL
      A0A5S9YIH5, A0A654GET1
      Conserved Domains (1) summary
      PLN02927
      Location:1 → 667
      PLN02927; antheraxanthin epoxidase/zeaxanthin epoxidase

    2. NM_126103.2 → NP_201504.2  zeaxanthin epoxidase (ZEP) (ABA1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201504.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YIH5, A0A654GET1
      Conserved Domains (2) summary
      PLN02927
      Location:1 → 609
      PLN02927; antheraxanthin epoxidase/zeaxanthin epoxidase
      cl21454
      Location:82 → 428
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGC7.1

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