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    LACS7 long-chain acyl-CoA synthetase 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832820, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LACS7
    Official Full Name
    long-chain acyl-CoA synthetase 7
    Primary source
    TAIR:AT5G27600
    Locus tag
    AT5G27600
    See related
    Araport:AT5G27600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLACS7; F15A18.60; F15A18_60; long-chain acyl-CoA synthetase 7
    Summary
    Encode peroxisomal long-chain acyl-CoA synthetase. Activates fatty acids for further metabolism. Interacts with PEX5.
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    Genomic context

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    See LACS7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Sequence:
    Chromosome: 5; NC_003076.8 (9742492..9747024)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like 89 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two long-chain acyl-CoA synthetases from Arabidopsis thaliana involved in peroxisomal fatty acid beta-oxidation. Fulda M, et al. Plant J, 2002 Oct. PMID 12366803
    2. Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids. De Marcos Lousa C, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23288899, Free PMC Article
    3. AtLACS7 interacts with the TPR domains of the PTS1 receptor PEX5. Bonsegna S, et al. Arch Biochem Biophys, 2005 Nov 15. PMID 16256065
    4. Arabidopsis contains nine long-chain acyl-coenzyme a synthetase genes that participate in fatty acid and glycerolipid metabolism. Shockey JM, et al. Plant Physiol, 2002 Aug. PMID 12177484, Free PMC Article
    5. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122642.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within response to ozone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    long-chain acyl-CoA synthetase 7
    NP_198112.2
    • long-chain acyl-CoA synthetase 7 (LACS7); FUNCTIONS IN: protein binding, long-chain fatty acid-CoA ligase activity; INVOLVED IN: response to salt stress, long-chain fatty acid metabolic process, response to ozone; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: long-chain acyl-CoA synthetase 6 (TAIR:AT3G05970.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9742492..9747024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122642.5 → NP_198112.2  long-chain acyl-CoA synthetase 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198112.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWV4, Q8LKS5
      UniProtKB/TrEMBL
      A0A5S9Y819, A0A654G5E6
      Conserved Domains (2) summary
      PLN02736
      Location:41 → 691
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:114 → 687
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LKS5.2

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