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    FDH formate dehydrogenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831330, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FDH
    Official Full Name
    formate dehydrogenase
    Primary source
    TAIR:AT5G14780
    Locus tag
    AT5G14780
    See related
    Araport:AT5G14780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtFDH1; formate dehydrogenase; FORMATE DEHYDROGENASE; T9L3.80; T9L3_80
    Summary
    Encodes a NAD-dependent formate dehydrogenase.
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    Genomic context

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    See FDH in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (4776733..4779526)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 66 Neighboring gene L-aspartate oxidase Neighboring gene PPR repeat protein Neighboring gene ARM repeat superfamily protein Neighboring gene pyrroline-5- carboxylate (P5C) reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens. Lee S, et al. PLoS One, 2022. PMID 35594245, Free PMC Article
    2. Formate dehydrogenase in Arabidopsis thaliana: characterization and possible targeting to the chloroplast. Olson BJ, et al. Plant Sci, 2000 Nov 6. PMID 11074273
    3. Degradation of the stress-responsive enzyme formate dehydrogenase by the RING-type E3 ligase Keep on Going and the ubiquitin 26S proteasome system. McNeilly D, et al. Plant Mol Biol, 2018 Feb. PMID 29270890
    4. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    5. Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction. Peltier JB, et al. Plant Cell, 2002 Jan. PMID 11826309, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens.
      Title: Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens.
    2. KEG is capable of attaching ubiquitin to FDH in in vitro assays and the turnover of FDH was increased when co-expressed with a functional KEG in planta, suggesting that KEG contributes to FDH degradation.
      Title: Degradation of the stress-responsive enzyme formate dehydrogenase by the RING-type E3 ligase Keep on Going and the ubiquitin 26S proteasome system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121482.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    formate dehydrogenase
    NP_196982.1
    • formate dehydrogenase (FDH); FUNCTIONS IN: NAD or NADH binding, binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, catalytic activity, cofactor binding; INVOLVED IN: response to cadmium ion, response to wounding; LOCATED IN: thylakoid, mitochondrion, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-3-phosphoglycerate dehydrogenase (TAIR:AT1G17745.1); Has 28984 Blast hits to 28977 proteins in 2707 species: Archae - 468; Bacteria - 17844; Metazoa - 730; Fungi - 1196; Plants - 566; Viruses - 5; Other Eukaryotes - 8175 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4776733..4779526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343371.1 → NP_001330044.1  formate dehydrogenase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9L1

    2. NM_001343372.1 → NP_001330045.1  formate dehydrogenase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9N1

    3. NM_121482.4 → NP_196982.1  formate dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196982.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7E4
      UniProtKB/TrEMBL
      A0A178UHK7, A0A5S9Y466
      Conserved Domains (1) summary
      PLN03139
      Location:2 → 384
      PLN03139; formate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7E4.1

    Gene LinkOut

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