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    ACD1 Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823622, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACD1
    Official Full Name
    Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein
    Primary source
    TAIR:AT3G44880
    Locus tag
    AT3G44880
    See related
    Araport:AT3G44880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACCELERATED CELL DEATH 1; LETHAL LEAF-SPOT 1 HOMOLOG; LLS1; PAO; PHEOPHORBIDE A OXYGENASE
    Summary
    Encodes a pheide a oxygenase (PAO). Accelerated cell death (acd1) mutants show rapid, spreading necrotic responses to both virulent and avirulent Pseudomonas syringae pv. maculicola or pv. tomato pathogens and to ethylene.
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    Genomic context

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    See ACD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (16383595..16386344)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene farnesoic acid carboxyl-O-methyltransferase Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ribosomal protein L9 Neighboring gene cation/H+ exchanger 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chlorophyll breakdown: pheophorbide a oxygenase is a Rieske-type iron-sulfur protein, encoded by the accelerated cell death 1 gene. Pruzinská A, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657372, Free PMC Article
    2. Arabidopsis mutants compromised for the control of cellular damage during pathogenesis and aging. Greenberg JT, et al. Plant J, 1993 Aug. PMID 8220484
    3. Nitric oxide deficiency accelerates chlorophyll breakdown and stability loss of thylakoid membranes during dark-induced leaf senescence in Arabidopsis. Liu F, et al. PLoS One, 2013. PMID 23418559, Free PMC Article
    4. Chlorophyll breakdown in senescent Arabidopsis leaves. Characterization of chlorophyll catabolites and of chlorophyll catabolic enzymes involved in the degreening reaction. Pruzinská A, et al. Plant Physiol, 2005 Sep. PMID 16113212, Free PMC Article
    5. Arabidopsis STAYGREEN-LIKE (SGRL) promotes abiotic stress-induced leaf yellowing during vegetative growth. Sakuraba Y, et al. FEBS Lett, 2014 Nov 3. PMID 25261252

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the double mutant pao1 nos1/noa1 retained the level of chlorophyll (Chl) during dark-induced leaf senescence.
      Title: Nitric oxide deficiency accelerates chlorophyll breakdown and stability loss of thylakoid membranes during dark-induced leaf senescence in Arabidopsis.
    2. PAO is involved in chlorophyll breakdown during leaf sensescence in A. thaliana.[PAO]
      Title: Chlorophyll breakdown in senescent Arabidopsis leaves. Characterization of chlorophyll catabolites and of chlorophyll catabolic enzymes involved in the degreening reaction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114357.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chlorophyllide a oxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pheophorbide a oxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fruit development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein
    NP_190074.1
    • ACCELERATED CELL DEATH 1 (ACD1); FUNCTIONS IN: iron-sulfur cluster binding, pheophorbide a oxygenase activity; INVOLVED IN: flower development, cell death, chlorophyll catabolic process, defense response to bacterium, incompatible interaction, fruit development; LOCATED IN: chloroplast, chloroplast inner membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rieske [2Fe-2S] iron-sulphur domain (InterPro:IPR017941), Pheophorbide a oxygenase (InterPro:IPR013626); BEST Arabidopsis thaliana protein match is: ACD1-like (TAIR:AT4G25650.1); Has 4072 Blast hits to 4065 proteins in 685 species: Archae - 4; Bacteria - 2839; Metazoa - 50; Fungi - 15; Plants - 409; Viruses - 0; Other Eukaryotes - 755 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16383595..16386344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114357.6 → NP_190074.1  Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04422, Q9FYC2
      UniProtKB/TrEMBL
      A0A178VII1, A0A5S9XHW2
      Conserved Domains (1) summary
      PLN02518
      Location:1 → 537
      PLN02518; pheophorbide a oxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FYC2.1

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