RAD51 RAS associated with diabetes protein 51 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RAD51
Official Full Name: RAS associated with diabetes protein 51
Primary source: TAIR:AT5G20850
Locus tag: AT5G20850
See related: Araport:AT5G20850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRAD51; F22D1.20; F22D1_20; RAS associated with diabetes protein 51
Summary: Encodes a homolog of yeast RAD51. Its mRNA is most abundant in early flower buds and is expressed at high levels in exponentially growing cells in suspension cultures and is induced in response to gamma radiation. Also involved in defense gene transcription during plant immune responses.
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Genomic context

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See RAD51 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 9

Sequence:: Chromosome: 5; NC_003076.8 (7070491..7072968, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types.
Title: Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types.
DNA-binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana.
Title: DNA-binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana.
The multi-BRCT domain protein DDRM2 promotes the recruitment of RAD51 to DNA damage sites to facilitate homologous recombination.
Title: The multi-BRCT domain protein DDRM2 promotes the recruitment of RAD51 to DNA damage sites to facilitate homologous recombination.
RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
Title: RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
Title: RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
Results suggest that RAD51-dependent homologous recombination acts as an essential backup to the telomerase for compensation of replicative telomere loss to ensure genome stability
Title: RAD51 and RTEL1 compensate telomere loss in the absence of telomerase.
Both AtRAD51 and AtDMC1 possess ATP hydrolyzing activity, filament formation activity and homologous pairing activity in vitro.
Title: Homologous pairing activities of Arabidopsis thaliana RAD51 and DMC1.
Although the presence of RAD51 protein provides essential support for the action of DMC1, these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
Title: Analysis of the impact of the absence of RAD51 strand exchange activity in Arabidopsis meiosis.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
Title: The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis.
RAD51 forms a protein complex with AtRAD51C-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Title: Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001343688.1

Supported by ESTs:

NM_122092.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA strand exchange activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via synthesis-dependent strand annealing	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic recombination-dependent replication fork processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to radiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RAS associated with diabetes protein 51

NP_568402.1

RAS associated with diabetes protein 51 (RAD51); FUNCTIONS IN: in 6 functions; INVOLVED IN: DNA repair, double-strand break repair, response to gamma radiation, response to radiation, DNA metabolic process; LOCATED IN: nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA repair Rad51/transcription factor NusA, alpha-helical (InterPro:IPR010995), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination/repair protein Rad51 (InterPro:IPR011941), Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632), DNA recombination/repair protein RecA, monomer-monomer interface (InterPro:IPR020587); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT3G22880.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

7070491..7072968 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122092.3 → NP_568402.1 RAS associated with diabetes protein 51 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568402.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P94102

UniProtKB/TrEMBL

A0A178UQK2, A0A5S9Y897, Q0WU10

Conserved Domains (1) summary

PLN03186
Location:1 → 342

PLN03186; DNA repair protein RAD51 homolog; Provisional
NM_001343688.1 → NP_001332342.1 RAS associated with diabetes protein 51 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BGT9, Q0WU10

Conserved Domains (1) summary

PLN03186
Location:1 → 302

PLN03186; DNA repair protein RAD51 homolog; Provisional