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    PRR1 pinoresinol reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840102, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRR1
    Official Full Name
    pinoresinol reductase 1
    Primary source
    TAIR:AT1G32100
    Locus tag
    AT1G32100
    See related
    Araport:AT1G32100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPRR1; F3C3.10; F3C3_10; pinoresinol reductase 1; PSEUDO-RESPONSE REGULATOR 1
    Summary
    Encodes a pinoresinol reductase involved in lignan biosynthesis. Expressed strongly in roots and less strongly in stems. Shows specificity for pinoresinol and not lariciresinol.
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    Genomic context

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    See PRR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (11546160..11548016, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene early-responsive to dehydration stress protein (ERD4) Neighboring gene miscRNA Neighboring gene serine/threonine-protein phosphatase 7 long form-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pinoresinol reductase 1 impacts lignin distribution during secondary cell wall biosynthesis in Arabidopsis. Zhao Q, et al. Phytochemistry, 2015 Apr. PMID 25107662
    2. PSEUDO RESPONSE REGULATORs stabilize CONSTANS protein to promote flowering in response to day length. Hayama R, et al. EMBO J, 2017 Apr 3. PMID 28270524, Free PMC Article
    3. Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis. Nakatsubo T, et al. J Biol Chem, 2008 Jun 6. PMID 18347017, Free PMC Article
    4. Evolution of plant defense mechanisms. Relationships of phenylcoumaran benzylic ether reductases to pinoresinol-lariciresinol and isoflavone reductases. Gang DR, et al. J Biol Chem, 1999 Mar 12. PMID 10066819
    5. TCP transcription factors link the regulation of genes encoding mitochondrial proteins with the circadian clock in Arabidopsis thaliana. Giraud E, et al. Plant Cell, 2010 Dec. PMID 21183706, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRR-mediated stabilization increases binding of CO to the promoter of FLOWERING LOCUS T (FT), leading to enhanced FT transcription and early flowering under these conditions.
      Title: PSEUDO RESPONSE REGULATORs stabilize CONSTANS protein to promote flowering in response to day length.
    2. an association of the lignan biosynthetic enzyme encoded by PrR1 with secondary cell wall biosynthesis in fiber cells
      Title: Pinoresinol reductase 1 impacts lignin distribution during secondary cell wall biosynthesis in Arabidopsis.
    3. AtPrR1 encoded by At1g32100 reduced both (+)- and (-)-pinoresinols to (+)- and (-)-lariciresinols efficiently with comparative k(cat)/K(m) values.
      Title: Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102944.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pinoresinol reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pinoresinol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pinoresinol reductase 1
    NP_174490.1
    • pinoresinol reductase 1 (PRR1); CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), NmrA-like (InterPro:IPR008030); BEST Arabidopsis thaliana protein match is: pinoresinol reductase 2 (TAIR:AT4G13660.1); Has 2085 Blast hits to 2085 proteins in 479 species: Archae - 27; Bacteria - 779; Metazoa - 2; Fungi - 496; Plants - 600; Viruses - 0; Other Eukaryotes - 181 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11546160..11548016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102944.3 → NP_174490.1  pinoresinol reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBG5, Q9FVQ6
      UniProtKB/TrEMBL
      A0A178WJY2, A0A5S9WKP6
      Conserved Domains (1) summary
      cd05259
      Location:11 → 312
      PCBER_SDR_a; phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FVQ6.1

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