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    THO2 THO2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839081, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THO2
    Official Full Name
    THO2
    Primary source
    TAIR:AT1G24706
    Locus tag
    AT1G24706
    See related
    Araport:AT1G24706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTHO2; EMB2793; EMBRYO DEFECTIVE 2793; F5A9.21; F5A9_21
    Summary
    Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
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    Genomic context

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    See THO2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    34
    Sequence:
    Chromosome: 1; NC_003070.9 (8741836..8755604)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. THO2, a core member of the THO/TREX complex, is required for microRNA production in Arabidopsis. Francisco-Mangilet AG, et al. Plant J, 2015 Jun. PMID 25976549
    2. Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene and endogenous siRNA biosynthesis. Yelina NE, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20634427, Free PMC Article
    3. A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Waidmann S, et al. Plant Cell, 2014 Nov. PMID 25387881, Free PMC Article
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. THO2, a core member of the THO/TREX complex, is required for microRNA production in Arabidopsis.
      Title: THO2, a core member of the THO/TREX complex, is required for microRNA production in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198157.1
    NM_001332661.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of THO complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    THO2
    NP_001185086.1
    • THO2; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: THO complex, subunitTHOC2, C-region (InterPro:IPR021418), THO complex, subunitTHOC2, N-region (InterPro:IPR021726).
    NP_173871.6
    • THO2; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: THO complex, subunitTHOC2, C-region (InterPro:IPR021418), THO complex, subunitTHOC2, N-region (InterPro:IPR021726); Has 19944 Blast hits to 14322 proteins in 730 species: Archae - 16; Bacteria - 829; Metazoa - 10835; Fungi - 2538; Plants - 1298; Viruses - 76; Other Eukaryotes - 4352 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8741836..8755604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332655.1 → NP_001321786.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W886, A0A1P8ARZ4, A0A384KN02, A0A7G2DWG2
      Conserved Domains (5) summary
      PRK12678
      Location:1333 → 1576
      PRK12678; transcription termination factor Rho; Provisional
      TIGR01622
      Location:1463 → 1580
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:912 → 1206
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:587 → 661
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:37 → 585
      THOC2_N; THO complex subunit 2 N-terminus

    2. NM_001332656.1 → NP_001321785.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7B6, A0A1P8ARY6, A0A384L8X5, A0A7G2DWG2
      Conserved Domains (5) summary
      PRK12678
      Location:1333 → 1576
      PRK12678; transcription termination factor Rho; Provisional
      TIGR01622
      Location:1463 → 1580
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:912 → 1206
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:587 → 661
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:37 → 585
      THOC2_N; THO complex subunit 2 N-terminus

    3. NM_001332657.1 → NP_001321784.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7B6, A0A1P8ARY6, A0A384L8X5, A0A7G2DWG2
      Conserved Domains (5) summary
      PRK12678
      Location:1333 → 1576
      PRK12678; transcription termination factor Rho; Provisional
      TIGR01622
      Location:1463 → 1580
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:912 → 1206
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:587 → 661
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:37 → 585
      THOC2_N; THO complex subunit 2 N-terminus

    4. NM_001332658.1 → NP_001321783.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7B6, A0A1P8ARY6, A0A384L8X5, A0A7G2DWG2
      Conserved Domains (5) summary
      PRK12678
      Location:1333 → 1576
      PRK12678; transcription termination factor Rho; Provisional
      TIGR01622
      Location:1463 → 1580
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:912 → 1206
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:587 → 661
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:37 → 585
      THOC2_N; THO complex subunit 2 N-terminus

    5. NM_001332659.1 → NP_001321782.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS07, A0A7G2DWG2

    6. NM_001332660.1 → NP_001321781.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS05, A0A7G2DWG2
      Conserved Domains (5) summary
      PRK12678
      Location:1244 → 1487
      PRK12678; transcription termination factor Rho; Provisional
      TIGR01622
      Location:1374 → 1491
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:823 → 1117
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:498 → 572
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:44 → 496
      THOC2_N; THO complex subunit 2 N-terminus

    7. NM_102309.6 → NP_173871.6  THO2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173871.6

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DWG2, F4IAT3
      Conserved Domains (5) summary
      COG0642
      Location:511 → 671
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam11262
      Location:912 → 1206
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:587 → 661
      Thoc2; Transcription- and export-related complex subunit
      pfam12871
      Location:1474 → 1566
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:37 → 585
      THOC2_N; THO complex subunit 2 N-terminus

    8. NM_001198157.1 → NP_001185086.1  THO2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185086.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IAT2, Q8GUG8, Q9FXJ7, Q9FXJ8
      UniProtKB/TrEMBL
      A0A5S9VXT6, A0A654ENI3
      Conserved Domains (5) summary
      COG0642
      Location:511 → 671
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam11262
      Location:912 → 1206
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:587 → 661
      Thoc2; Transcription- and export-related complex subunit
      pfam12871
      Location:1474 → 1566
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:37 → 585
      THOC2_N; THO complex subunit 2 N-terminus

    9. NM_001332661.1 → NP_001321780.1  THO2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARZ0, A0A7G2DWG2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IAT2.1

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