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    TPS5 trehalose phosphatase/synthase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827498, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPS5
    Official Full Name
    trehalose phosphatase/synthase 5
    Primary source
    TAIR:AT4G17770
    Locus tag
    AT4G17770
    See related
    Araport:AT4G17770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTPS5; DL4920W; FCAALL.9; TREHALOSE -6-PHOSPHATASE SYNTHASE S5; trehalose phosphatase/synthase 5
    Summary
    Encodes an enzyme putatively involved in trehalose biosynthesis. The protein has a trehalose synthase (TPS)-like domain that may or may not be active as well as a trehalose phosphatase (TPP)-like domain. Phosphorylated TPS5 extracted from Arabidopsis cells binds directly to 14-3-3 isoforms.
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    Genomic context

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    See TPS5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (9876172..9880386)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene PCNA domain-containing protein Neighboring gene tRNA-Trp Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene myb domain protein 39 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trehalose phosphate synthase 5-dependent trehalose metabolism modulates basal defense responses in Arabidopsis thaliana. Wang X, et al. J Integr Plant Biol, 2019 Apr. PMID 30058771
    2. Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose. Harthill JE, et al. Plant J, 2006 Jul. PMID 16771775
    3. The transcriptional co-activator MBF1c is a key regulator of thermotolerance in Arabidopsis thaliana. Suzuki N, et al. J Biol Chem, 2008 Apr 4. PMID 18201973
    4. Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Ramon M, et al. Plant Cell Environ, 2009 Aug. PMID 19344332
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings provide insight into the function of TPS5-dependent trehalose metabolism in plant basal defense responses.
      Title: Trehalose phosphate synthase 5-dependent trehalose metabolism modulates basal defense responses in Arabidopsis thaliana.
    2. 2-deoxyglucose stimulates Threonine 49 phosphorylation of endogenous TPS5 in Arabidopsis cells.
      Title: Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117886.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables trehalose-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    trehalose phosphatase/synthase 5
    NP_567538.1
    • trehalose phosphatase/synthase 5 (TPS5); FUNCTIONS IN: transferase activity, transferring glycosyl groups, trehalose-phosphatase activity; INVOLVED IN: trehalose biosynthetic process, metabolic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HAD-superfamily hydrolase, subfamily IIB (InterPro:IPR006379), Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: UDP-Glycosyltransferase / trehalose-phosphatase family protein (TAIR:AT1G68020.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9876172..9880386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341241.1 → NP_001329809.1  trehalose phosphatase/synthase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23617, Q8GWQ1
      UniProtKB/TrEMBL
      A0A178UUB8, A0A384LAK9, W8PUL2
      Conserved Domains (1) summary
      PLN02205
      Location:1 → 850
      PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]

    2. NM_117886.3 → NP_567538.1  trehalose phosphatase/synthase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23617, Q8GWQ1
      UniProtKB/TrEMBL
      A0A178UUB8, A0A384LAK9, W8PUL2
      Conserved Domains (1) summary
      PLN02205
      Location:1 → 850
      PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23617.2

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