U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RNS2 ribonuclease 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818563, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RNS2
    Official Full Name
    ribonuclease 2
    Primary source
    TAIR:AT2G39780
    Locus tag
    AT2G39780
    See related
    Araport:AT2G39780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ribonuclease 2; T5I7.8; T5I7_8
    Summary
    Encodes the main endoribonuclease activity in plant cells and localizes to the endoplasmic reticulum (ER), ER-derived structures, and vacuoles. It is essential for normal ribosomal RNA recycling.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RNS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (16591117..16593775)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glucose-1-phosphate adenylyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial glycoprotein family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana. Chen Y, et al. Plant Mol Biol, 2024 Jan 24. PMID 38265739
    2. Cell growth and homeostasis are disrupted in arabidopsis rns2-2 mutants missing the main vacuolar RNase activity. Morriss SC, et al. Ann Bot, 2017 Nov 28. PMID 28961890, Free PMC Article
    3. Localization of RNS2 ribonuclease to the vacuole is required for its role in cellular homeostasis. Floyd BE, et al. Planta, 2017 Apr. PMID 28025674
    4. RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants. Hillwig MS, et al. Proc Natl Acad Sci U S A, 2011 Jan 18. PMID 21199950, Free PMC Article
    5. Regulation of S-like ribonuclease levels in Arabidopsis. Antisense inhibition of RNS1 or RNS2 elevates anthocyanin accumulation. Bariola PA, et al. Plant Physiol, 1999 Jan. PMID 9880376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana.
      Title: RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana.
    2. Lack of rRNA recycling in rns2-2 cells triggers a change in carbon flux, which is redirected through the pentose phosphate pathway to produce ribose-5-phosphate for de novo nucleoside synthesis. rRNA or ribosome turnover is thus essential for cellular homeostasis, probably through maintenance of nucleoside levels as part of the salvage pathway.
      Title: Cell growth and homeostasis are disrupted in arabidopsis rns2-2 mutants missing the main vacuolar RNase activity.
    3. intracellular retention and localization within the vacuole are critical for its cellular function
      Title: Localization of RNS2 ribonuclease to the vacuole is required for its role in cellular homeostasis.
    4. RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay.
      Title: RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_001125006.1
    NM_129536.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease T2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ribonuclease 2
    NP_001118478.1
    • ribonuclease 2 (RNS2); FUNCTIONS IN: ribonuclease T2 activity, endoribonuclease activity, RNA binding; INVOLVED IN: aging; LOCATED IN: intracellular; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ribonuclease T2 (InterPro:IPR001568), Ribonuclease T2, active site (InterPro:IPR018188); BEST Arabidopsis thaliana protein match is: Ribonuclease T2 family protein (TAIR:AT1G14220.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_030524.1
    • ribonuclease 2 (RNS2); FUNCTIONS IN: ribonuclease T2 activity, endoribonuclease activity, RNA binding; INVOLVED IN: aging; LOCATED IN: intracellular, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ribonuclease T2 (InterPro:IPR001568), Ribonuclease T2, active site (InterPro:IPR018188); BEST Arabidopsis thaliana protein match is: Ribonuclease T2 family protein (TAIR:AT1G14220.1); Has 2318 Blast hits to 2317 proteins in 471 species: Archae - 0; Bacteria - 380; Metazoa - 295; Fungi - 231; Plants - 1299; Viruses - 5; Other Eukaryotes - 108 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16591117..16593775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129536.5 → NP_030524.1  ribonuclease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_030524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42814, Q42136
      UniProtKB/TrEMBL
      A0A5S9X5I7, A0A7G2EHU0, Q1ECE2
      Conserved Domains (1) summary
      pfam00445
      Location:32 → 219
      Ribonuclease_T2; Ribonuclease T2 family

    2. NM_001125006.1 → NP_001118478.1  ribonuclease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F1N6, A0A7G2EHU0, F4IW05
      Conserved Domains (1) summary
      pfam00445
      Location:32 → 187
      Ribonuclease_T2; Ribonuclease T2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42814.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools