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    plcg1 phospholipase C, gamma 1 [ Danio rerio (zebrafish) ]

    Gene ID: 373867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plcg1provided by ZNC
    Official Full Name
    phospholipase C, gamma 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030421-3
    See related
    Ensembl:ENSDARG00000038442 AllianceGenome:ZFIN:ZDB-GENE-030421-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj46f04; wu:fj46f04; wu:fj57a05
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Acts upstream of or within several processes, including blood vessel morphogenesis; fin regeneration; and hemopoiesis. Predicted to be active in ruffle membrane. Is expressed in brain; heart; intermediate cell mass of mesoderm; ovary; and vasculature. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See plcg1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (2790177..2870869)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (2848501..2927173)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene zgc:114123 Neighboring gene DNA topoisomerase Ib Neighboring gene zinc fingers and homeoboxes 3b Neighboring gene RAB5 interacting factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development. Ma AC, et al. Exp Hematol, 2007 Mar. PMID 17309817
    2. miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Pedrioli DM, et al. Mol Cell Biol, 2010 Jul. PMID 20479124, Free PMC Article
    3. Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. de Oliveira MB, et al. Development, 2021 Feb 19. PMID 33547133, Free PMC Article
    4. An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation. Lister AL, et al. Gen Comp Endocrinol, 2008 Oct. PMID 18722378
    5. The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk. Mauri C, et al. Angiogenesis, 2021 May. PMID 33677657, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
      Title: Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish.
    2. genetic analyses suggest that Vegf/Plcg1 signaling acts at multiple time points and in different signaling contexts to mediate distinct aspects of artery development
      Title: A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development.
    3. muscle of the heart uses the VEGF-PLCgamma1 cascade to control the strength of the heart beat
      Title: VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of epithelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of angioblast cell migration involved in selective angioblast sprouting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
    Names
    dead beat
    ded
    NP_919388.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194407.1 → NP_919388.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

      See identical proteins and their annotated locations for NP_919388.1

      Status: PROVISIONAL

      Source sequence(s)
      AY163168
      UniProtKB/TrEMBL
      Q804J6
      Related
      ENSDARP00000120537.1, ENSDART00000135781.2
      Conserved Domains (11) summary
      smart00149
      Location:949 → 1064
      PLCYc; Phospholipase C, catalytic domain (part); domain Y
      cd00275
      Location:1082 → 1206
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:314 → 472
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:658 → 760
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:540 → 644
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11970
      Location:786 → 845
      SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
      cd13234
      Location:857 → 928
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd13362
      Location:29 → 151
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      pfam00169
      Location:865 → 924
      PH; PH domain
      pfam09279
      Location:242 → 306
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl17171
      Location:484 → 521
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      2790177..2870869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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