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    negr1 neuronal growth regulator 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    negr1provided by ZNC
    Official Full Name
    neuronal growth regulator 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-27
    See related
    Ensembl:ENSDARG00000021607 AllianceGenome:ZFIN:ZDB-GENE-040822-27
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:100871
    Summary
    Enables identical protein binding activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in head. Orthologous to human NEGR1 (neuronal growth regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See negr1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (36942966..37247931)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (36964849..37189770)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene TRAF3 interacting protein 2-like Neighboring gene uncharacterized LOC137495990 Neighboring gene zinc finger, RAN-binding domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development. Habicher J, et al. Genes (Basel), 2024 Mar 14. PMID 38540422, Free PMC Article
    2. Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections. Wang X, et al. J Biol Chem, 2016 Feb 19. PMID 26740623, Free PMC Article
    3. Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. Zuccarini G, et al. Int J Mol Sci, 2019 Dec 25. PMID 31881740, Free PMC Article
    4. Neuroprotective effect of plasmalogens on AlCl(3)-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center. Zhang J, et al. Neurosci Lett, 2024 Jan 1. PMID 37979715
    5. Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. Jiang P, et al. PLoS One, 2018. PMID 29634734, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development.
      Title: The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC100871

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal growth regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003851.1 → NP_001003851.1  neuronal growth regulator 1 precursor

      See identical proteins and their annotated locations for NP_001003851.1

      Status: PROVISIONAL

      Source sequence(s)
      AF241637
      UniProtKB/TrEMBL
      A0A4W4, A0A564, A0A8N7XJH4, E7FAG9
      Related
      ENSDARP00000038588.6, ENSDART00000028895.7
      Conserved Domains (4) summary
      smart00408
      Location:153 → 208
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:236 → 312
      IG_like; Immunoglobulin like
      pfam07679
      Location:140 → 222
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:42 → 121
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      36942966..37247931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302511.4 → XP_009300786.1  neuronal growth regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B3I9
      Conserved Domains (4) summary
      smart00408
      Location:153 → 208
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:236 → 312
      IG_like; Immunoglobulin like
      pfam07679
      Location:140 → 222
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:42 → 121
      Ig; Immunoglobulin domain

    RNA

    1. XR_011015800.1 RNA Sequence

    2. XR_011015802.1 RNA Sequence

    3. XR_011015801.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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