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    dap1b death associated protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 58094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dap1bprovided by ZNC
    Official Full Name
    death associated protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000511-4
    See related
    Ensembl:ENSDARG00000086842 AllianceGenome:ZFIN:ZDB-GENE-000511-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb369; hm:zeh0189; zgc:136540
    Summary
    Enables ribosome binding activity; translation initiation factor binding activity; and translation repressor activity. Involved in ribosome hibernation. Is expressed in several structures, including central nervous system; hatching gland; hypochord; neural tube; and pronephric duct. Orthologous to human DAPL1 (death associated protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dap1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (52378481..52403754, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (52836297..52864215, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496509 Neighboring gene bromodomain adjacent to zinc finger domain protein 2B Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1b Neighboring gene uncharacterized LOC137496510 Neighboring gene death-associated protein-like 1 homolog Neighboring gene NME/NM23 family member 9 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 Neighboring gene membrane associated ring-CH-type finger 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, et al. Nature, 2023 Jan. PMID 36653451, Free PMC Article
    2. Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Huo X, et al. Sci Rep, 2019 Feb 6. PMID 30728369, Free PMC Article
    3. Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung. Zheng W, et al. PLoS One, 2011. PMID 21887364, Free PMC Article
    4. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136540

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome hibernation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome hibernation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death-associated protein-like 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131573.2 → NP_571648.1  death-associated protein-like 1 homolog

      See identical proteins and their annotated locations for NP_571648.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115168
      UniProtKB/Swiss-Prot
      A0A0R4IYW0, Q1RM22, Q9I9N0
      Related
      ENSDARP00000141912.1, ENSDART00000171721.2
      Conserved Domains (1) summary
      pfam15228
      Location:14 → 108
      DAP; Death-associated protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      52378481..52403754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357715.3 → XP_017213204.1  death-associated protein-like 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      A0A0R4IYW0, Q1RM22, Q9I9N0
      Conserved Domains (1) summary
      pfam15228
      Location:14 → 108
      DAP; Death-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I9N0.1 GenPept UniProtKB/Swiss-Prot:Q9I9N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.