nfe2l3 nfe2 like bZIP transcription factor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nfe2l3provided by ZNC
Official Full Name: nfe2 like bZIP transcription factor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2334
See related: Ensembl:ENSDARG00000019810 AllianceGenome:ZFIN:ZDB-GENE-040426-2334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Nrf3; zgc:77291; wu:fa04h04
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in midbrain hindbrain boundary; pectoral fin; pectoral fin bud; and pharyngeal arch. Orthologous to human NFE2L3 (NFE2 like bZIP transcription factor 3). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (18143593..18152533, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (18680738..18689768, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi63b09.y1 (e-PCR)
- UniSTS:197795

fa04h04.s1 (e-PCR)
- UniSTS:202204

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor erythroid 2-related factor 3

Names: nuclear factor (erythroid-derived 2)-like 3; nuclear factor, erythroid 2-like 3; nuclear factor-like 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213231.1 → NP_998396.1 nuclear factor erythroid 2-related factor 3

See identical proteins and their annotated locations for NP_998396.1

Status: PROVISIONAL

Source sequence(s)

BC069060

UniProtKB/TrEMBL

L0AMC5, Q6NTE5

Related

ENSDARP00000146557.1, ENSDART00000193264.1

Conserved Domains (1) summary

cd14720
Location:507 → 574

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

18143593..18152533 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173768.5 → XP_005173825.1 nuclear factor erythroid 2-related factor 3 isoform X1

See identical proteins and their annotated locations for XP_005173825.1

UniProtKB/TrEMBL

L0AMC5, Q6NTE5

Related

ENSDARP00000150367.1, ENSDART00000190182.1

Conserved Domains (1) summary

cd14720
Location:507 → 574

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain