sdhdb succinate dehydrogenase complex, subunit D, integral membrane protein b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sdhdbprovided by ZNC
Official Full Name: succinate dehydrogenase complex, subunit D, integral membrane protein bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040822-17
See related: Ensembl:ENSDARG00000030139 AllianceGenome:ZFIN:ZDB-GENE-040822-17
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sdhd; sdhda; cybS-B; zgc:100986
Summary: Predicted to enable heme binding activity and ubiquinone binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in female organism. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (21684446..21692594, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (21748714..21756862, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquinone binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquinone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial

Names: SDHD1; malate dehydrogenase [quinone] cytochrome b small subunit; succinate dehydrogenase complex subunit D-B; succinate dehydrogenase complex, subunit D, integral membrane protein a; succinate-ubiquinone oxidoreductase cytochrome b small subunit B; succinate-ubiquinone reductase membrane anchor subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004004.2 → NP_001004004.1 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial

See identical proteins and their annotated locations for NP_001004004.1

Status: PROVISIONAL

Source sequence(s)

BC079507

UniProtKB/Swiss-Prot

Q68FN7

Related

ENSDARP00000039864.4, ENSDART00000039865.5

Conserved Domains (1) summary

cd03496
Location:59 → 157

SQR_TypeC_CybS; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Eukaryotic SQRs reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric ...