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    syt11a synaptotagmin XIa [ Danio rerio (zebrafish) ]

    Gene ID: 406769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    syt11aprovided by ZNC
    Official Full Name
    synaptotagmin XIaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2815
    See related
    Ensembl:ENSDARG00000057913 AllianceGenome:ZFIN:ZDB-GENE-040426-2815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    syt11; fc52d10; fi68d01; zgc:55556; wu:fc52d10; wu:fi68d01
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and vesicle fusion. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; exocytic vesicle; and synapse. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See syt11a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (23982416..24032417)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (24398193..24448194)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene SNAP associated protein Neighboring gene SMAD family member 10a Neighboring gene Ras-like without CAAX 1 Neighboring gene peroxisomal biogenesis factor 11 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article
    2. Synaptotagmin gene content of the sequenced genomes. Craxton M. BMC Genomics, 2004 Jul 6. PMID 15238157, Free PMC Article
    3. Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Pan W, et al. Sci Rep, 2022 Jun 16. PMID 35710785, Free PMC Article
    4. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article
    5. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-11a
    Names
    synaptotagmin XI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213460.2 → NP_998625.2  synaptotagmin-11a

      Status: VALIDATED

      Source sequence(s)
      BX548249
      UniProtKB/TrEMBL
      A0A8M1PJG8, F1RD06
      Related
      ENSDARP00000075119.5, ENSDART00000080673.6
      Conserved Domains (2) summary
      cd08404
      Location:312 → 449
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
      cl14603
      Location:179 → 290
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      23982416..24032417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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