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    lrmp lymphoid-restricted membrane protein [ Danio rerio (zebrafish) ]

    Gene ID: 567234, updated on 4-Jan-2025

    Summary

    Official Symbol
    lrmpprovided by ZNC
    Official Full Name
    lymphoid-restricted membrane proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-152
    See related
    Ensembl:ENSDARG00000045574 AllianceGenome:ZFIN:ZDB-GENE-041210-152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    irag2; fi05h08; wu:fi05h08; si:dkey-172o10.2; si:dkey-172o10.3; si:dkey-172o10.4
    Summary
    Involved in several processes, including mRNA transport; pronuclear fusion; and pronuclear migration. Located in several cellular components, including endoplasmic reticulum membrane; microtubule cytoskeleton; and nuclear membrane. Is expressed in blastomere and unfertilized egg. Orthologous to human IRAG2 (inositol 1,4,5-triphosphate receptor associated 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See lrmp in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17253421..17282531, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17264445..17293558, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491539 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene branched chain amino-acid transaminase 1, cytosolic Neighboring gene insulin-like growth factor 1 Neighboring gene nucleoporin 37 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in centrosome PubMed 
    located_in chromatin PubMed 
    located_in chromosome  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane PubMed 
    located_in membrane  
    located_in mitotic spindle PubMed 
    located_in mitotic spindle pole PubMed 
    located_in nuclear membrane PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    inositol 1,4,5-triphosphate receptor associated 2
    Names
    fue
    futile cycle

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346283.1 → NP_001333212.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      JX297440
      UniProtKB/TrEMBL
      A0A8M9Q5Z4
      Related
      ENSDARP00000143787.2, ENSDART00000178686.2
    2. NM_001346284.1 → NP_001333213.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JX297440, JX297441
      UniProtKB/Swiss-Prot
      J9WMP5, Q5RHB5
      UniProtKB/TrEMBL
      A0A8M9Q5Z4
      Related
      ENSDARP00000118448.1, ENSDART00000135730.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      17253421..17282531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300316.4 → XP_009298591.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ARP2, A0A8M9Q5Z4
      Conserved Domains (6) summary
      pfam05781
      Location:1008 → 1484
      MRVI1; MRVI1 protein
      pfam14658
      Location:230 → 295
      EF-hand_9; EF-hand domain
      pfam14662
      Location:347 → 538
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam14772
      Location:433 → 535
      NYD-SP28; Sperm tail
      pfam16043
      Location:356 → 472
      DUF4795; Domain of unknown function (DUF4795)
      cl03075
      Location:637 → 833
      GrpE; nucleotide exchange factor GrpE
    2. XM_068219707.1 → XP_068075808.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q5Z4
    3. XM_009300318.4 → XP_009298593.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

      See identical proteins and their annotated locations for XP_009298593.1

      UniProtKB/TrEMBL
      A0A8M9Q5Z4
      Conserved Domains (6) summary
      pfam05781
      Location:1012 → 1418
      MRVI1; MRVI1 protein
      pfam14658
      Location:230 → 295
      EF-hand_9; EF-hand domain
      pfam14662
      Location:347 → 538
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam14772
      Location:433 → 535
      NYD-SP28; Sperm tail
      pfam16043
      Location:356 → 472
      DUF4795; Domain of unknown function (DUF4795)
      cl03075
      Location:637 → 833
      GrpE; nucleotide exchange factor GrpE
    4. XM_009300317.4 → XP_009298592.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

      See identical proteins and their annotated locations for XP_009298592.1

      UniProtKB/Swiss-Prot
      J9WMP5, Q5RHB5
      UniProtKB/TrEMBL
      A0A8M9Q5Z4
      Conserved Domains (6) summary
      pfam05781
      Location:1012 → 1447
      MRVI1; MRVI1 protein
      pfam14658
      Location:230 → 295
      EF-hand_9; EF-hand domain
      pfam14662
      Location:347 → 538
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam14772
      Location:433 → 535
      NYD-SP28; Sperm tail
      pfam16043
      Location:356 → 472
      DUF4795; Domain of unknown function (DUF4795)
      cl03075
      Location:637 → 833
      GrpE; nucleotide exchange factor GrpE
    5. XM_005164777.5 → XP_005164834.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

      See identical proteins and their annotated locations for XP_005164834.1

      UniProtKB/TrEMBL
      A0A8M9Q5Z4, A0A8M9QBC0
      Conserved Domains (4) summary
      pfam05781
      Location:1012 → 1488
      MRVI1; MRVI1 protein
      pfam14658
      Location:230 → 295
      EF-hand_9; EF-hand domain
      pfam14662
      Location:347 → 537
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl25732
      Location:273 → 809
      SMC_N; RecF/RecN/SMC N terminal domain
    6. XM_021475075.2 → XP_021330750.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5Z4, A0A8M9QBC0
      Conserved Domains (4) summary
      pfam05781
      Location:1012 → 1488
      MRVI1; MRVI1 protein
      pfam14658
      Location:230 → 295
      EF-hand_9; EF-hand domain
      pfam14662
      Location:347 → 537
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl25732
      Location:273 → 809
      SMC_N; RecF/RecN/SMC N terminal domain
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