junbb JunB proto-oncogene, AP-1 transcription factor subunit b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: junbbprovided by ZNC
Official Full Name: JunB proto-oncogene, AP-1 transcription factor subunit bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2666
See related: Ensembl:ENSDARG00000104773 AllianceGenome:ZFIN:ZDB-GENE-040426-2666
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: junbl; zgc:63933; wu:fa95h09; wu:fj44e11; wu:fj68b07
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within fin regeneration and lymph vessel development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; fin; nervous system; optic vesicle; and pectoral fin bud. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and melanoma. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (7654409..7656059, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (7768569..7770219, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration.
Title: AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration.

Submit: New GeneRIF Correction

General gene information

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Markers

fa95h09.x1 (e-PCR)
- UniSTS:202601

fj68b07.x1 (e-PCR)
- UniSTS:199844

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: JunB proto-oncogene, AP-1 transcription factor subunit b

Names: jun B proto-oncogene b; jun B proto-oncogene, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212750.1 → NP_997915.1 JunB proto-oncogene, AP-1 transcription factor subunit b

See identical proteins and their annotated locations for NP_997915.1

Status: PROVISIONAL

Source sequence(s)

BC053154

UniProtKB/TrEMBL

Q7T3E3

Related

ENSDARP00000131822.1, ENSDART00000170917.2

Conserved Domains (2) summary

cd14696
Location:233 → 293

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam03957
Location:5 → 220

Jun; Jun-like transcription factor