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    ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 [ Danio rerio (zebrafish) ]

    Gene ID: 493605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndufs1provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-478
    See related
    Ensembl:ENSDARG00000028546 AllianceGenome:ZFIN:ZDB-GENE-030131-478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92209; wu:fb33h05
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to act upstream of or within ATP synthesis coupled electron transport. Predicted to be located in membrane. Is expressed in muscle. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndufs1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (13206516..13231951)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12972981..12998416)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene INO80 complex subunit Db Neighboring gene potassium inwardly rectifying channel subfamily J member 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Conserved function of caspase-8 in apoptosis during bony fish evolution. Sakata S, et al. Gene, 2007 Jul 1. PMID 17459614, Free PMC Article
    2. Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. Shi L, et al. Int J Mol Sci, 2023 May 18. PMID 37240290, Free PMC Article
    3. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
    4. Reprimo tissue-specific expression pattern is conserved between zebrafish and human. Figueroa RJ, et al. PLoS One, 2017. PMID 28562620, Free PMC Article
    5. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Ling XP, et al. Environ Sci Pollut Res Int, 2012 Nov. PMID 22767353

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 1
    NP_001007766.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007765.1 → NP_001007766.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

      See identical proteins and their annotated locations for NP_001007766.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085651
      UniProtKB/TrEMBL
      Q5RKM2
      Related
      ENSDARP00000028571.6, ENSDART00000036927.7
      Conserved Domains (5) summary
      smart00929
      Location:117 → 157
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
      PRK09130
      Location:35 → 727
      PRK09130; NADH dehydrogenase subunit G; Validated
      cd02773
      Location:253 → 634
      MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
      pfam09326
      Location:682 → 714
      NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
      pfam13510
      Location:33 → 111
      Fer2_4; 2Fe-2S iron-sulfur cluster binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      13206516..13231951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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