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    bag6 BCL2 associated athanogene 6 [ Danio rerio (zebrafish) ]

    Gene ID: 83910, updated on 4-Jan-2025

    Summary

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    Official Symbol
    bag6provided by ZNC
    Official Full Name
    BCL2 associated athanogene 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010501-5
    See related
    Ensembl:ENSDARG00000075892 AllianceGenome:ZFIN:ZDB-GENE-010501-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bat3; wu:fi30e10
    Summary
    Predicted to enable misfolded protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ERAD pathway. Predicted to act upstream of or within apoptotic process and chromatin organization. Predicted to be located in extracellular region and nucleus. Predicted to be part of BAT3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See bag6 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34618340..34658061, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34760369..34800106, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 13a Neighboring gene LINE-1 reverse transcriptase homolog Neighboring gene lymphotoxin alpha (TNF superfamily, member 1) Neighboring gene tumor necrosis factor b (TNF superfamily, member 2)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel tumor necrosis factor (TNF) gene present in tandem with theTNF-alpha gene on the same chromosome in teleosts. Savan R, et al. Immunogenetics, 2005 Apr. PMID 15759114
    2. On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis. Baeken MW, et al. J Cell Biochem, 2022 Jan. PMID 33942360
    3. Presence of two tumor necrosis factor (tnf)-α homologs on different chromosomes of zebrafish (Danio rerio) and medaka (Oryzias latipes). Kinoshita S, et al. Mar Genomics, 2014 Feb. PMID 24269726
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large proline-rich protein BAG6
    Names
    HLA-B-associated transcript 3
    etID62210.15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201288.1 → NP_958445.1  large proline-rich protein BAG6

      See identical proteins and their annotated locations for NP_958445.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052476
      UniProtKB/TrEMBL
      Q7SZF4
      Related
      ENSDARP00000102380.1, ENSDART00000110964.3
      Conserved Domains (3) summary
      cd01809
      Location:9 → 79
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:9 → 79
      UBQ; Ubiquitin homologues
      pfam12057
      Location:282 → 400
      DUF3538; Domain of unknown function (DUF3538)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34618340..34658061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157765.3 → XP_005157822.1  large proline-rich protein BAG6 isoform X1

      UniProtKB/TrEMBL
      A0A2R8QDI1, A0A8M2B4R7
      Related
      ENSDARP00000151719.1, ENSDART00000186605.1
      Conserved Domains (3) summary
      cd01809
      Location:9 → 79
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:9 → 79
      UBQ; Ubiquitin homologues
      pfam12057
      Location:282 → 400
      DUF3538; Domain of unknown function (DUF3538)
    Nucleotide Protein Strain
    Heading Accession and Version

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