ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ikbkgprovided by ZNC
Official Full Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050327-68
See related: Ensembl:ENSDARG00000017037 AllianceGenome:ZFIN:ZDB-GENE-050327-68
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nemo; fj33c07; wu:fj33c07; zgc:113492
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within I-kappaB phosphorylation and positive regulation of canonical NF-kappaB signal transduction. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in periderm. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (18574220..18597715, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (18647866..18671384, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within I-kappaB phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NF-kappa-B essential modulator

Names: ikky; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014344.2 → NP_001014366.1 NF-kappa-B essential modulator

See identical proteins and their annotated locations for NP_001014366.1

Status: PROVISIONAL

Source sequence(s)

BC091829

UniProtKB/TrEMBL

Q58EN3

Related

ENSDARP00000027612.7, ENSDART00000008847.9

Conserved Domains (2) summary

cd09803
Location:416 → 502

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:43 → 110

NEMO; NF-kappa-B essential modulator NEMO

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

18574220..18597715 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162070.5 → XP_005162127.1 NF-kappa-B essential modulator isoform X1

UniProtKB/TrEMBL

A0A8M2B8Y6, F1QHG7

Related

ENSDARP00000107606.2, ENSDART00000122280.3

Conserved Domains (2) summary

cd09803
Location:432 → 518

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:43 → 110

NEMO; NF-kappa-B essential modulator NEMO