fkbp14 FKBP prolyl isomerase 14 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fkbp14provided by ZNC
Official Full Name: FKBP prolyl isomerase 14provided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-210
See related: Ensembl:ENSDARG00000040695 AllianceGenome:ZFIN:ZDB-GENE-040801-210
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd36a03; zgc:91851; wu:fd36a03
Summary: Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be located in endoplasmic reticulum. Is expressed in notochord. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (20295033..20304805)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (20489214..20498986)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP14

Names: FK506 binding protein 14

NP_001003471.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003471.1 → NP_001003471.1 peptidyl-prolyl cis-trans isomerase FKBP14 precursor

See identical proteins and their annotated locations for NP_001003471.1

Status: PROVISIONAL

Source sequence(s)

BC078342

UniProtKB/TrEMBL

Q6DBV9

Related

ENSDARP00000059618.4, ENSDART00000059619.5

Conserved Domains (3) summary

pfam00254
Location:38 → 132

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam13499
Location:141 → 204

EF-hand_7; EF-hand domain pair

cl08302
Location:142 → 204

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...