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    mms22l MMS22-like, DNA repair protein [ Danio rerio (zebrafish) ]

    Gene ID: 563411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mms22lprovided by ZNC
    Official Full Name
    MMS22-like, DNA repair proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3869
    See related
    Ensembl:ENSDARG00000074691 AllianceGenome:ZFIN:ZDB-GENE-030131-3869
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc56d09; wu:fc56d09; zgc:194596
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination and replication fork processing. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of DNA damage. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mms22l in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32281430..32304764, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32327401..32350803, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator family member 6 Neighboring gene kelch-like family member 32 Neighboring gene uncharacterized LOC137487924 Neighboring gene uncharacterized LOC137487845

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Gallagher TL, et al. Dev Biol, 2017 Sep 1. PMID 28648842, Free PMC Article
    2. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein MMS22-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130601.1 → NP_001124073.1  protein MMS22-like

      See identical proteins and their annotated locations for NP_001124073.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163291
      UniProtKB/Swiss-Prot
      B3DIY3
      Related
      ENSDARP00000155250.1, ENSDART00000191408.1
      Conserved Domains (2) summary
      pfam14910
      Location:29 → 739
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:851 → 1226
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      32281430..32304764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158355.5 → XP_005158412.1  protein MMS22-like isoform X1

      See identical proteins and their annotated locations for XP_005158412.1

      UniProtKB/TrEMBL
      A0A8M9P7Y3, F1Q905
      Related
      ENSDARP00000115566.1, ENSDART00000134381.2
      Conserved Domains (2) summary
      pfam14910
      Location:29 → 739
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:851 → 1226
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    2. XM_021466713.2 → XP_021322388.1  protein MMS22-like isoform X1

      UniProtKB/TrEMBL
      A0A8M9P7Y3, F1Q905
      Conserved Domains (2) summary
      pfam14910
      Location:29 → 739
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:851 → 1226
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3DIY3.1 GenPept UniProtKB/Swiss-Prot:B3DIY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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