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    fxr1 FMR1 autosomal homolog 1 [ Danio rerio (zebrafish) ]

    Gene ID: 327220, updated on 9-Dec-2024

    Summary

    Official Symbol
    fxr1provided by ZNC
    Official Full Name
    FMR1 autosomal homolog 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5431
    See related
    Ensembl:ENSDARG00000022968 AllianceGenome:ZFIN:ZDB-GENE-030131-5431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66226; wu:fb16f11; wu:fd18c10
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity; molecular condensate scaffold activity; and translation regulator activity. Acts upstream of or within several processes, including muscle cell development; skeletal muscle tissue development; and somitogenesis. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytoplasmic stress granule; neuron projection; and nucleus. Is expressed in several structures, including adaxial cell; heart; musculature system; neurons; and skeletal muscle myoblast. Human ortholog(s) of this gene implicated in congenital myopathy 9A and congenital myopathy 9B. Orthologous to human FXR1 (FMR1 autosomal homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See fxr1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (37542727..37565393, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (37607809..37630475, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene SOX2 overlapping transcript Neighboring gene SRY-box transcription factor 2 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 19 Neighboring gene uncharacterized LOC137488977 Neighboring gene tetratricopeptide repeat domain 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular condensate scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membraneless organelle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of long-term neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation at presynapse, modulating synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular membraneless organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein FXR1
    Names
    fragile X mental retardation syndrome-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312881.1NP_001299810.1  RNA-binding protein FXR1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CU468728
      UniProtKB/TrEMBL
      A0A9F7TY55
      Related
      ENSDARP00000124192.1, ENSDART00000149482.3
      Conserved Domains (7) summary
      smart00322
      Location:220280
      KH; K homology RNA-binding domain
      cd00105
      Location:286352
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:70115
      Agenet; Agenet domain
      pfam12235
      Location:354463
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:483556
      FXR_C1; Fragile X-related 1 protein C-terminal region 2
      pfam16097
      Location:601642
      FXR_C3; Fragile X-related 1 protein C-terminal region 3
      cl12013
      Location:117230
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_201301.2NP_958458.2  RNA-binding protein FXR1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      CK028714, CK029878, CN317510, CU468728, EH586881
      UniProtKB/Swiss-Prot
      A0A8M1P7M4, A0A8M1PJ50, F1QLR3
      Related
      ENSDARP00000095251.3, ENSDART00000104478.4
      Conserved Domains (7) summary
      smart00322
      Location:220280
      KH; K homology RNA-binding domain
      cd00105
      Location:286352
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:70115
      Agenet; Agenet domain
      pfam12235
      Location:354463
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:483557
      FXR_C1; Fragile X-related 1 protein C-terminal region 2
      pfam16097
      Location:575616
      FXR_C3; Fragile X-related 1 protein C-terminal region 3
      cl12013
      Location:117230
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      37542727..37565393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)