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    sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha [ Danio rerio (zebrafish) ]

    Gene ID: 336867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sgtaprovided by ZNC
    Official Full Name
    small glutamine rich tetratricopeptide repeat co-chaperone alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8811
    See related
    Ensembl:ENSDARG00000019941 AllianceGenome:ZFIN:ZDB-GENE-030131-8811
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk20d10; zgc:55741; zgc:77080; wu:fa05b08; wu:fc52b05; wu:fk20d10; si:dkey-6d5.2
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be part of TRC complex. Predicted to be active in membrane. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sgta in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (14771906..14813053, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (14714247..14755359, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene adenosine receptor A1-like Neighboring gene si:ch73-60h1.1 Neighboring gene uncharacterized LOC137490417 Neighboring gene uncharacterized LOC110440118 Neighboring gene uncharacterized LOC110440095 Neighboring gene uncharacterized LOC137496679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Names
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212764.1 → NP_997929.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha

      See identical proteins and their annotated locations for NP_997929.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067176
      UniProtKB/TrEMBL
      A0A8M3B6S6, F1QI71, Q6NXA1
      Related
      ENSDARP00000027982.6, ENSDART00000004920.8
      Conserved Domains (3) summary
      sd00006
      Location:91 → 119
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 63
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:105 → 208
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      14771906..14813053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479556.2 → XP_021335231.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6S6, F1QI71, Q6NXA1
      Conserved Domains (3) summary
      sd00006
      Location:91 → 119
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 63
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:105 → 208
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    2. XM_068224117.1 → XP_068080218.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6S6, F1QI71, Q6NXA1

    3. XM_068224116.1 → XP_068080217.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6S6, F1QI71, Q6NXA1

    4. XM_068224118.1 → XP_068080219.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6S6, F1QI71, Q6NXA1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394807.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      261568..267719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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