cpa1 carboxypeptidase A1 (pancreatic) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpa1provided by ZNC
Official Full Name: carboxypeptidase A1 (pancreatic)provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-438
See related: Ensembl:ENSDARG00000030915 AllianceGenome:ZFIN:ZDB-GENE-050522-438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fd42g02; zgc:112280
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in pancreas. Orthologous to human CPA1 (carboxypeptidase A1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (18448194..18453986, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (18351794..18357586, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carboxypeptidase A1

NP_001018318.1

EC 3.4.17.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020482.2 → NP_001018318.1 carboxypeptidase A1 precursor

See identical proteins and their annotated locations for NP_001018318.1

Status: PROVISIONAL

Source sequence(s)

BC095726

UniProtKB/TrEMBL

Q4VBJ2

Related

ENSDARP00000024981.7, ENSDART00000005877.8

Conserved Domains (2) summary

pfam02244
Location:27 → 99

Propep_M14; Carboxypeptidase activation peptide

cl11393
Location:117 → 416

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins