U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    orc1 origin recognition complex, subunit 1 [ Danio rerio (zebrafish) ]

    Gene ID: 554509, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    orc1provided by ZNC
    Official Full Name
    origin recognition complex, subunit 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6960
    See related
    Ensembl:ENSDARG00000039217 AllianceGenome:ZFIN:ZDB-GENE-030131-6960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    orc1l; zgc:55976; wu:fa11h08
    Summary
    Predicted to enable DNA replication origin binding activity. Acts upstream of or within several processes, including chordate embryonic development; cilium assembly; and response to yeast. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in proliferative region and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See orc1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33931736..33947874)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33947050..33963189)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member A1b (aldehyde reductase) Neighboring gene pre-mRNA processing factor 38A Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene lnc RNA tyrosine kinase with immunoglobulin-like and EGF-like domains 1, antisense Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Bicknell LS, et al. Nat Genet, 2011 Feb 27. PMID 21358633
    2. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Maerz LD, et al. Eur J Hum Genet, 2019 May. PMID 30696958, Free PMC Article
    3. The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Kuo AJ, et al. Nature, 2012 Mar 7. PMID 22398447, Free PMC Article
    4. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
    5. Oxidative stress, cell cycle arrest, DNA damage and apoptosis in adult zebrafish (Danio rerio) induced by tris(1,3-dichloro-2-propyl) phosphate. Chen H, et al. Aquat Toxicol, 2018 Jan. PMID 29149642

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC55976

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to yeast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    origin recognition complex subunit 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199933.1 → NP_956227.1  origin recognition complex subunit 1

      See identical proteins and their annotated locations for NP_956227.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047200
      UniProtKB/TrEMBL
      Q7ZYW6
      Related
      ENSDARP00000126330.1, ENSDART00000151213.3
      Conserved Domains (4) summary
      cd08768
      Location:820 → 903
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
      smart00382
      Location:575 → 725
      AAA; ATPases associated with a variety of cellular activities
      cd04719
      Location:45 → 166
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      pfam00004
      Location:579 → 724
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      33931736..33947874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166281.5 → XP_005166338.1  origin recognition complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDS9, F1QLF9
      Related
      ENSDARP00000110729.2, ENSDART00000130492.4
      Conserved Domains (4) summary
      cd08768
      Location:822 → 905
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
      smart00382
      Location:577 → 727
      AAA; ATPases associated with a variety of cellular activities
      cd04719
      Location:45 → 168
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      pfam00004
      Location:581 → 726
      AAA; ATPase family associated with various cellular activities (AAA)

    2. XM_021476877.2 → XP_021332552.1  origin recognition complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PM45
      Related
      ENSDARP00000154560.1, ENSDART00000191909.1
      Conserved Domains (3) summary
      cd08768
      Location:783 → 866
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
      cd04719
      Location:45 → 168
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      cl26671
      Location:445 → 822
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

    3. XM_068221726.1 → XP_068077827.1  origin recognition complex subunit 1 isoform X3

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395259.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      240662..256824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.