ryk receptor like tyrosine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rykprovided by ZNC
Official Full Name: receptor like tyrosine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070209-277
See related: Ensembl:ENSDARG00000007231 AllianceGenome:ZFIN:ZDB-GENE-070209-277
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb37b12; wu:fi05b06; zgc:158381
Summary: Enables Wnt-protein binding activity. Acts upstream of or within Wnt signaling pathway, calcium modulating pathway; convergent extension; and release of sequestered calcium ion into cytosol. Located in plasma membrane. Is expressed in heart tube; nervous system; notochord; post-vent region; and somite. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (27514559..27615439)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (27523929..27624878)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RYK and VANGL2 proteins form a complex, whereas RYK also activated RhoA, a downstream effector of PCP signaling.
Title: The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling.
Data suggest that full-length Ryk conveys Wnt5b signals in a directional manner during gastrulation.
Title: Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G45985 (e-PCR)
- UniSTS:106787

fb37b12.x1 (e-PCR)
- UniSTS:203153

fb74d10.y1 (e-PCR)
- UniSTS:191201

fb92c05.y1 (e-PCR)
- UniSTS:191742

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
NOT enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase RYK

Names: RYK receptor-like tyrosine kinase

NP_001077295.1

EC 2.7.10.1

XP_005165988.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083826.1 → NP_001077295.1 tyrosine-protein kinase RYK precursor

See identical proteins and their annotated locations for NP_001077295.1

Status: PROVISIONAL

Source sequence(s)

BC131872

UniProtKB/TrEMBL

A0A8M1NCR3, A2RRV7

Related

ENSDARP00000073853.3, ENSDART00000079397.4

Conserved Domains (3) summary

cd05043
Location:320 → 600

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

pfam02019
Location:70 → 184

WIF; WIF domain

pfam07714
Location:327 → 593

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

27514559..27615439

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165931.5 → XP_005165988.1 tyrosine-protein kinase RYK isoform X1

UniProtKB/TrEMBL

A0A8M2BD97, E7FAI5

Related

ENSDARP00000106622.2, ENSDART00000128985.4

Conserved Domains (3) summary

cd05043
Location:348 → 628

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

pfam02019
Location:70 → 184

WIF; WIF domain

pfam07714
Location:355 → 621

Pkinase_Tyr; Protein tyrosine kinase