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    pals2a protein associated with LIN7 2, MAGUK p55 family member a [ Danio rerio (zebrafish) ]

    Gene ID: 402878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pals2aprovided by ZNC
    Official Full Name
    protein associated with LIN7 2, MAGUK p55 family member aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050506-35
    See related
    Ensembl:ENSDARG00000056892 AllianceGenome:ZFIN:ZDB-GENE-050506-35
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mpp6a; im:6899520
    Summary
    Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in cephalic musculature; hypaxial myotome region; myotome; pectoral fin musculature; and somite. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pals2a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (21442362..21489562, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (21636543..21683743, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 3b Neighboring gene gasdermin Eb Neighboring gene serine/threonine kinase 31 Neighboring gene discoidin domain receptor tyrosine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Giera S, et al. Elife, 2018 May 29. PMID 29809138, Free PMC Article
    2. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 6a
    Names
    membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
    protein associated with LIN7 2, MAGUK family member a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256189.1 → NP_001243118.1  MAGUK p55 subfamily member 6a

      Status: VALIDATED

      Source sequence(s)
      BX469919, CU905502
      UniProtKB/TrEMBL
      A0A8M1P2G7, F1QKE3
      Related
      ENSDARP00000123608.2, ENSDART00000146914.4
      Conserved Domains (5) summary
      smart00569
      Location:13 → 66
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:229 → 286
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      cd00992
      Location:138 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68 → 119
      L27; L27 domain
      cl27059
      Location:347 → 537
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      21442362..21489562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466656.2 → XP_021322331.1  MAGUK p55 subfamily member 6a isoform X2

      UniProtKB/TrEMBL
      A0A2R8Q1T2, A0A8M9PJD3
      Related
      ENSDARP00000144755.1, ENSDART00000193081.1
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:218 → 275
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      cd00992
      Location:127 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain
      cl27059
      Location:336 → 526
      Guanylate_kin; Guanylate kinase

    2. XM_021466654.2 → XP_021322329.1  MAGUK p55 subfamily member 6a isoform X1

      UniProtKB/TrEMBL
      A0A8M1P2G7, F1QKE3
      Related
      ENSDARP00000151087.1, ENSDART00000186017.1
      Conserved Domains (5) summary
      smart00569
      Location:13 → 66
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:229 → 286
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      cd00992
      Location:138 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68 → 119
      L27; L27 domain
      cl27059
      Location:347 → 537
      Guanylate_kin; Guanylate kinase

    3. XM_021466655.2 → XP_021322330.1  MAGUK p55 subfamily member 6a isoform X2

      UniProtKB/TrEMBL
      A0A2R8Q1T2, A0A8M9PJD3
      Related
      ENSDARP00000147717.1, ENSDART00000186493.1
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:218 → 275
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      cd00992
      Location:127 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain
      cl27059
      Location:336 → 526
      Guanylate_kin; Guanylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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