adgrl4 adhesion G protein-coupled receptor L4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adgrl4provided by ZNC
Official Full Name: adhesion G protein-coupled receptor L4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2689
See related: Ensembl:ENSDARG00000013653 AllianceGenome:ZFIN:ZDB-GENE-040426-2689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eltd1; fd10a02; zgc:63629; wu:fd10a02
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; eye; liver; pleuroperitoneal region; and ventral mesoderm. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (7383213..7410314, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (7373374..7400475, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor L4

Names: EGF, latrophilin and seven transmembrane domain containing 1; EGF, latrophilin and seven transmembrane domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213367.2 → NP_998532.2 adhesion G protein-coupled receptor L4 precursor

Status: VALIDATED

Source sequence(s)

CU464206

UniProtKB/Swiss-Prot

F1QUS5, Q7SY09

UniProtKB/TrEMBL

A0A140TAT8, A0A8N1Z4G1

Related

ENSDARP00000014501.8, ENSDART00000009859.9

Conserved Domains (6) summary

smart00179
Location:110 → 143

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:60 → 93

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01825
Location:416 → 457

GPS; GPCR proteolysis site, GPS, motif

pfam16489
Location:188 → 386

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl21504
Location:34 → 56

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cl21561
Location:469 → 705

7tm_4; Olfactory receptor