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    napepld N-acyl phosphatidylethanolamine phospholipase D [ Danio rerio (zebrafish) ]

    Gene ID: 568061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    napepldprovided by ZNC
    Official Full Name
    N-acyl phosphatidylethanolamine phospholipase Dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3856
    See related
    Ensembl:ENSDARG00000009252 AllianceGenome:ZFIN:ZDB-GENE-030131-3856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc56b11; nape-pld; wu:fc56b11; zgc:158854; si:dkey-65m5.3
    Summary
    Predicted to enable N-acylphosphatidylethanolamine-specific phospholipase D activity. Predicted to be involved in N-acylethanolamine metabolic process and N-acylphosphatidylethanolamine metabolic process. Predicted to act upstream of or within phospholipid catabolic process. Predicted to be located in Golgi membrane and early endosome membrane. Predicted to be active in cytoplasm. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See napepld in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20480399..20485508, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20759419..20765007, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4a Neighboring gene leucine-rich repeats and transmembrane domains 2a Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene decapping mRNA 1B Neighboring gene integrator complex subunit 13 Neighboring gene sialic acid-binding Ig-like lectin 7 Neighboring gene Ras association domain family member 8b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Forner-Piquer I, et al. Environ Pollut, 2020 Sep. PMID 32417572
    2. The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish. Krug RG 2nd, et al. PLoS One, 2018. PMID 29304078, Free PMC Article
    3. Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. Martella A, et al. FASEB J, 2016 Dec. PMID 27623930
    4. Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Knuth MM, et al. J Lipid Res, 2021. PMID 34673019, Free PMC Article
    5. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Forner-Piquer I, et al. Environ Pollut, 2018 Oct. PMID 29793103

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158854

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
    NP_001074082.2
    XP_005164954.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080613.2 → NP_001074082.2  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

      See identical proteins and their annotated locations for NP_001074082.2

      Status: VALIDATED

      Source sequence(s)
      BX248410, CD014813, EB868982
      UniProtKB/TrEMBL
      A0A2R8RJ40, A0A8M1NCU2, A0A8M2BC81
      Related
      ENSDARP00000154110.1, ENSDART00000183276.1
      Conserved Domains (2) summary
      COG2220
      Location:97 → 353
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cl23716
      Location:98 → 283
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      20480399..20485508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164897.5 → XP_005164954.2  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A2R8RJ40, A0A8M1NCU2, A0A8M2BC81
      Related
      ENSDARP00000146191.1, ENSDART00000187240.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.