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    ran RAN, member RAS oncogene family [ Danio rerio (zebrafish) ]

    Gene ID: 30572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ranprovided by ZNC
    Official Full Name
    RAN, member RAS oncogene familyprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-88
    See related
    Ensembl:ENSDARG00000057026 AllianceGenome:ZFIN:ZDB-GENE-990415-88
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc16b04; wu:fc16b04
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and magnesium ion binding activity. Acts upstream of or within neural retina development. Predicted to be located in cytosol and nuclear envelope. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; digestive system; eye; pronephros; and splanchnocranium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ran in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21685512..21693988)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21388267..21396743)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8b Neighboring gene uncharacterized LOC103908747 Neighboring gene syntaxin 3b Neighboring gene lysine (K)-specific demethylase 2Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development. Hu R, et al. FASEB J, 2019 Apr. PMID 30624971
    2. Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes. Lin CY, et al. Int J Dev Biol, 2015. PMID 26864484
    3. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
    4. Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Hunter MV, et al. Nat Commun, 2021 Nov 1. PMID 34725363, Free PMC Article
    5. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GTP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural retina development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding nuclear protein Ran
    Names
    GTPase Ran
    ras-related nuclear protein
    NP_571384.1
    XP_005173151.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131309.3 → NP_571384.1  GTP-binding nuclear protein Ran

      See identical proteins and their annotated locations for NP_571384.1

      Status: VALIDATED

      Source sequence(s)
      CT955967, EH499718
      UniProtKB/Swiss-Prot
      P79735, Q7ZU75
      UniProtKB/TrEMBL
      Q6GTE7
      Related
      ENSDARP00000108629.2, ENSDART00000128717.4
      Conserved Domains (2) summary
      cd00877
      Location:10 → 175
      Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
      PTZ00132
      Location:1 → 215
      PTZ00132; GTP-binding nuclear protein Ran; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      21685512..21693988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173094.5 → XP_005173151.1  GTP-binding nuclear protein Ran isoform X1

      See identical proteins and their annotated locations for XP_005173151.1

      UniProtKB/Swiss-Prot
      P79735, Q7ZU75
      UniProtKB/TrEMBL
      Q6GTE7
      Related
      ENSDARP00000121831.1, ENSDART00000144503.3
      Conserved Domains (2) summary
      cd00877
      Location:10 → 175
      Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
      PTZ00132
      Location:1 → 215
      PTZ00132; GTP-binding nuclear protein Ran; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79735.1 GenPept UniProtKB/Swiss-Prot:P79735

    Gene LinkOut

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