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    cenpe centromere protein E [ Danio rerio (zebrafish) ]

    Gene ID: 767754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cenpeprovided by ZNC
    Official Full Name
    centromere protein Eprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-860
    See related
    Ensembl:ENSDARG00000063385 AllianceGenome:ZFIN:ZDB-GENE-060929-860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc06a10; zgc:152925
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule-based movement and mitotic cell cycle. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cenpe in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (260012..296057)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (264833..300878)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-1, b Neighboring gene G protein-coupled receptor kinase 1 a Neighboring gene uncharacterized LOC103911743 Neighboring gene growth arrest-specific 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinesin-7 CENP-E regulates cell division, gastrulation and organogenesis in development. Yu KW, et al. Eur J Cell Biol, 2020 Aug. PMID 32800279
    2. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Lin X, et al. Life (Basel), 2022 Sep 16. PMID 36143477, Free PMC Article
    3. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
    4. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article
    5. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152925

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    centromere-associated protein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327759.1 → NP_001314688.1  centromere-associated protein E

      Status: PROVISIONAL

      Source sequence(s)
      CU179747
      UniProtKB/TrEMBL
      A0A8M1P2Y6, A0A8M2BFG4, E7F2U4
      Related
      ENSDARP00000099552.3, ENSDART00000111806.5
      Conserved Domains (7) summary
      smart00129
      Location:6 → 343
      KISc; Kinesin motor, catalytic domain. ATPase
      TIGR02168
      Location:1468 → 2193
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01374
      Location:6 → 337
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam01576
      Location:801 → 1826
      Myosin_tail_1; Myosin tail
      pfam08172
      Location:984 → 1100
      CASP_C; CASP C terminal
      cl14813
      Location:1935 → 2053
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
      cl19219
      Location:1430 → 1517
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      260012..296057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168005.5 → XP_005168062.1  centromere-associated protein E isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFG2, A0A8M2BFG4
      Conserved Domains (7) summary
      smart00129
      Location:6 → 343
      KISc; Kinesin motor, catalytic domain. ATPase
      TIGR02168
      Location:1468 → 2193
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01374
      Location:6 → 337
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam01576
      Location:801 → 1826
      Myosin_tail_1; Myosin tail
      pfam08172
      Location:984 → 1100
      CASP_C; CASP C terminal
      cl14813
      Location:1935 → 2053
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
      cl19219
      Location:1430 → 1517
      DUF342; Protein of unknown function (DUF342)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001076721.1: Suppressed sequence

      Description
      NM_001076721.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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