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    pdia5 protein disulfide isomerase family A, member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 556162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdia5provided by ZNC
    Official Full Name
    protein disulfide isomerase family A, member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030521-5
    See related
    Ensembl:ENSDARG00000069242 AllianceGenome:ZFIN:ZDB-GENE-030521-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb441; wu:fb98h09; zgc:172235
    Summary
    Predicted to enable protein disulfide isomerase activity. Acts upstream of or within hemopoiesis. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alar plate midbrain region; anterior axial hypoblast; digestive system; fin; and nervous system. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pdia5 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (37754845..37839334)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (37945050..38029539)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 4 Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba Neighboring gene uncharacterized LOC137496490 Neighboring gene uncharacterized LOC137496491 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene adenylate cyclase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells. Chen YC, et al. PLoS One, 2012. PMID 22514630, Free PMC Article
    2. Stress-immune responses and DNA protection function of thioredoxin domain containing 12 in zebrafish (Danio rerio). Kulatunga DCM, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30359749
    3. Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters. Vacca F, et al. J Physiol, 2022 May. PMID 35413133, Free PMC Article
    4. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article
    5. B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. Zhu LY, et al. J Immunol, 2014 Mar 15. PMID 24532580

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase A5
    NP_001107048.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113576.1 → NP_001107048.1  protein disulfide-isomerase A5 precursor

      See identical proteins and their annotated locations for NP_001107048.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154606
      UniProtKB/TrEMBL
      A8WG75
      Related
      ENSDARP00000091365.4, ENSDART00000100592.5
      Conserved Domains (3) summary
      cd02997
      Location:407 → 510
      PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
      cd03067
      Location:36 → 147
      PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
      TIGR01130
      Location:181 → 512
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      37754845..37839334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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