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    sec22bb SEC22 homolog B, vesicle trafficking protein b [ Danio rerio (zebrafish) ]

    Gene ID: 327277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sec22bbprovided by ZNC
    Official Full Name
    SEC22 homolog B, vesicle trafficking protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5488
    See related
    Ensembl:ENSDARG00000100435 AllianceGenome:ZFIN:ZDB-GENE-030131-5488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sec22l1b; wu:fd20b06
    Summary
    Predicted to enable SNAP receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vesicle fusion with Golgi apparatus. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; and melanosome. Predicted to be part of SNARE complex. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sec22bb in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (19504011..19512270)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (19471926..19480185)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ER degradation enhancer, mannosidase alpha-like 3 Neighboring gene si:ch73-281k2.5 Neighboring gene N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) Neighboring gene notch receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish retinoid-related orphan receptor (ror) gene family. Flores MV, et al. Gene Expr Patterns, 2007 Apr. PMID 17374568
    2. The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects. Nishiwaki Y, et al. Dev Cell, 2013 May 28. PMID 23725763
    3. Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development. Guillemyn B, et al. J Bone Miner Res, 2023 Nov. PMID 37718532
    4. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicle-trafficking protein SEC22b-B
    Names
    SEC22 vesicle trafficking protein homolog B, b
    SEC22, vesicle trafficking protein-like 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328526.1 → NP_001315455.1  vesicle-trafficking protein SEC22b-B isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT573380, EH489983, EH493956, EH528230, EH596279
      UniProtKB/TrEMBL
      A0A0R4IQP5, A0A8M1PAE1, A7MCK9
      Related
      ENSDARP00000137821.2, ENSDART00000158859.2
      Conserved Domains (3) summary
      COG5143
      Location:12 → 192
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
      cd15866
      Location:136 → 199
      R-SNARE_SEC22; SNARE motif of SEC22
      pfam13774
      Location:41 → 107
      Longin; Regulated-SNARE-like domain

    2. NM_201302.2 → NP_958459.1  vesicle-trafficking protein SEC22b-B isoform 2

      See identical proteins and their annotated locations for NP_958459.1

      Status: VALIDATED

      Source sequence(s)
      CT573380, EH489983, EH493956, EH528230, EH596279
      UniProtKB/Swiss-Prot
      Q7SXP0
      Related
      ENSDARP00000136767.1, ENSDART00000159044.2
      Conserved Domains (3) summary
      COG5143
      Location:12 → 188
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
      cd15866
      Location:132 → 195
      R-SNARE_SEC22; SNARE motif of SEC22
      pfam13774
      Location:37 → 103
      Longin; Regulated-SNARE-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      19504011..19512270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXP0.1 GenPept UniProtKB/Swiss-Prot:Q7SXP0

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