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    ncf1 neutrophil cytosolic factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 378966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncf1provided by ZNC
    Official Full Name
    neutrophil cytosolic factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031006-6
    See related
    Ensembl:ENSDARG00000033735 AllianceGenome:ZFIN:ZDB-GENE-031006-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb893
    Summary
    Predicted to enable superoxide-generating NADPH oxidase activator activity. Acts upstream of or within defense response to fungus and respiratory burst. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Is expressed in cardiovascular system; extension; macrophage; and myeloid leukocyte. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease 1; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ncf1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61432541..61445697, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (60747820..60760976, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cytosolic arginine sensor for mTORC1 subunit 2 Neighboring gene RCC1 like Neighboring gene RNA polymerase II subunit J Neighboring gene alkB homolog 4, lysine demthylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth. Brothers KM, et al. Eukaryot Cell, 2011 Jul. PMID 21551247, Free PMC Article
    2. Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart. Reuter H, et al. Cells, 2022 Jan 20. PMID 35159152, Free PMC Article
    3. Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Sipka T, et al. Front Immunol, 2021. PMID 33841419, Free PMC Article
    4. Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish. Pase L, et al. Curr Biol, 2012 Oct 9. PMID 22940471
    5. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Natarajan N, et al. Circulation, 2018 May 15. PMID 29348261, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory burst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within respiratory burst IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neutrophil cytosol factor 1
    Names
    p47phox

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030071.2 → NP_001025242.1  neutrophil cytosol factor 1

      See identical proteins and their annotated locations for NP_001025242.1

      Status: PROVISIONAL

      Source sequence(s)
      AY972158
      UniProtKB/TrEMBL
      Q4Z8P3
      Related
      ENSDARP00000050897.4, ENSDART00000050898.5
      Conserved Domains (5) summary
      cd06887
      Location:6 → 123
      PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
      cd12021
      Location:162 → 214
      SH3_p47phox_1; First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      cd12022
      Location:232 → 284
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:354 → 407
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:286 → 335
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      61432541..61445697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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