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    uchl5 ubiquitin carboxyl-terminal hydrolase L5 [ Danio rerio (zebrafish) ]

    Gene ID: 406357, updated on 9-Dec-2024

    Summary

    Official Symbol
    uchl5provided by ZNC
    Official Full Name
    ubiquitin carboxyl-terminal hydrolase L5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2051
    See related
    Ensembl:ENSDARG00000103404 AllianceGenome:ZFIN:ZDB-GENE-040426-2051
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:85615; wu:fj17f09
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See uchl5 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (24220937..24233856)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (24194373..24207292)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 Neighboring gene glutaredoxin 2 Neighboring gene regulator of G protein signaling 2 Neighboring gene regulator of G protein signaling 13b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type peptidase activity  
    enables hydrolase activity  
    enables peptidase activity  
    enables proteasome binding  
    Component Evidence Code Pubs
    part_of Ino80 complex  
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    NP_998249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213084.1 → NP_998249.1  ubiquitin carboxyl-terminal hydrolase isozyme L5

      See identical proteins and their annotated locations for NP_998249.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067545
      UniProtKB/TrEMBL
      A0A8N1TST1, Q6NWL6
      Related
      ENSDARP00000141540.1, ENSDART00000165380.2
      Conserved Domains (1) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      24220937..24233856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395352.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      288538..302379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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