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    slka STE20-like kinase a [ Danio rerio (zebrafish) ]

    Gene ID: 568838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slkaprovided by ZNC
    Official Full Name
    STE20-like kinase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050411-66
    See related
    Ensembl:ENSDARG00000061525 AllianceGenome:ZFIN:ZDB-GENE-050411-66
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slkn; fk52g01; im:7150762; wu:fk52g01; si:ch211-223p8.7
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; regulation of apoptotic process; and regulation of cell migration. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slka in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24781188..24826449, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24650738..24696018, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene SWI5-dependent homologous recombination repair protein 1 Neighboring gene collagen, type XVII, alpha 1b Neighboring gene si:ch211-223p8.8 Neighboring gene zgc:153981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    STE20-like serine/threonine-protein kinase
    NP_001139073.1
    XP_005156928.1
    XP_005156929.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145601.1 → NP_001139073.1  STE20-like serine/threonine-protein kinase

      Status: PROVISIONAL

      Source sequence(s)
      AL929005
      UniProtKB/TrEMBL
      A0A8M1NQ55, B7ZD09
      Related
      ENSDARP00000113992.1, ENSDART00000142745.3
      Conserved Domains (3) summary
      smart00220
      Location:34 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28 → 310
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:986 → 1126
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      24781188..24826449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156872.5 → XP_005156929.1  STE20-like serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2Y0
      Conserved Domains (3) summary
      smart00220
      Location:34 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28 → 310
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:1010 → 1150
      PKK; Polo kinase kinase

    2. XM_005156871.5 → XP_005156928.1  STE20-like serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3N5, F1Q5H3
      Related
      ENSDARP00000082219.5, ENSDART00000087786.6
      Conserved Domains (3) summary
      smart00220
      Location:34 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28 → 310
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:1017 → 1157
      PKK; Polo kinase kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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