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    hacl1 2-hydroxyacyl-CoA lyase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hacl1provided by ZNC
    Official Full Name
    2-hydroxyacyl-CoA lyase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2058
    See related
    Ensembl:ENSDARG00000020529 AllianceGenome:ZFIN:ZDB-GENE-040426-2058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    phyh2; zgc:76920; wu:fd42e11
    Summary
    Predicted to enable thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hacl1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (20167845..20194379)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (20362026..20388560)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 28b Neighboring gene chromosome 16 C2orf66 homolog Neighboring gene collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. Qvit N, et al. J Biol Chem, 2016 Jun 24. PMID 27129213, Free PMC Article
    2. Loss of Function Mutations in NNT Are Associated With Left Ventricular Noncompaction. Bainbridge MN, et al. Circ Cardiovasc Genet, 2015 Aug. PMID 26025024, Free PMC Article
    3. Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Gao P, et al. Invest Ophthalmol Vis Sci, 2022 May 2. PMID 35616930, Free PMC Article
    4. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2-hydroxyacyl-CoA lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase 1
    Names
    phytanoyl-CoA 2-hydroxylase 2
    NP_998250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213085.1 → NP_998250.1  2-hydroxyacyl-CoA lyase 1

      See identical proteins and their annotated locations for NP_998250.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066580
      UniProtKB/TrEMBL
      Q6NYI5
      Related
      ENSDARP00000005715.8, ENSDART00000004031.10
      Conserved Domains (4) summary
      cd07035
      Location:8 → 160
      TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
      PRK09259
      Location:5 → 552
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
      cd02004
      Location:367 → 550
      TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
      pfam00205
      Location:193 → 322
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      20167845..20194379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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