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    pcyt1aa phosphate cytidylyltransferase 1A, choline a [ Danio rerio (zebrafish) ]

    Gene ID: 550327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcyt1aaprovided by ZNC
    Official Full Name
    phosphate cytidylyltransferase 1A, choline aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-108
    See related
    Ensembl:ENSDARG00000011233 AllianceGenome:ZFIN:ZDB-GENE-050417-108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110237
    Summary
    Predicted to enable choline-phosphate cytidylyltransferase activity and phosphatidylcholine binding activity. Predicted to act upstream of or within CDP-choline pathway. Predicted to be active in endoplasmic reticulum. Is expressed in swim bladder. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pcyt1aa in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (9755411..9780424)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (9957676..9982139)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-170o4.1 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene adaptor related protein complex 2 subunit mu 1a Neighboring gene annexin A13, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish. Chen T, et al. Genetics, 2018 Mar. PMID 29339408, Free PMC Article
    2. Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Sun SX, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 Apr. PMID 36708962
    3. Identification of p53-target genes in Danio rerio. Mandriani B, et al. Sci Rep, 2016 Sep 1. PMID 27581768, Free PMC Article
    4. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    choline-phosphate cytidylyltransferase A
    Names
    phosphate cytidylyltransferase 1, choline, alpha a
    NP_001017634.1
    XP_021335893.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017634.1 → NP_001017634.1  choline-phosphate cytidylyltransferase A

      See identical proteins and their annotated locations for NP_001017634.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092816
      UniProtKB/TrEMBL
      Q568K8
      Related
      ENSDARP00000026096.7, ENSDART00000018524.8
      Conserved Domains (1) summary
      cd02174
      Location:72 → 221
      CCT; CTP:phosphocholine cytidylyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      9755411..9780424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480218.2 → XP_021335893.1  choline-phosphate cytidylyltransferase A isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q8R8
      Conserved Domains (1) summary
      cd02174
      Location:72 → 221
      CCT; CTP:phosphocholine cytidylyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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