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    orai1a ORAI calcium release-activated calcium modulator 1a [ Danio rerio (zebrafish) ]

    Gene ID: 566671, updated on 4-Jan-2025

    Summary

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    Official Symbol
    orai1aprovided by ZNC
    Official Full Name
    ORAI calcium release-activated calcium modulator 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110721-1
    See related
    Ensembl:ENSDARG00000011515 AllianceGenome:ZFIN:ZDB-GENE-110721-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to act upstream of or within adaptive immune response. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

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    See orai1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (40276329..40288223)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (40236727..40248634)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 34a Neighboring gene lysine (K)-specific demethylase 2Ba Neighboring gene apelin receptor a Neighboring gene TBC1 domain family, member 10Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Wasilewska I, et al. Genes (Basel), 2019 Mar 18. PMID 30889933, Free PMC Article
    2. Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. Gupta RK, et al. Int J Mol Sci, 2020 Aug 27. PMID 32867296, Free PMC Article
    3. Identification of Ca(2+) signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres. Tse MK, et al. Sci China Life Sci, 2018 Nov. PMID 29931586
    4. stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae. Wasilewska I, et al. Cells, 2020 May 21. PMID 32455839, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium release-activated calcium channel protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      40276329..40288223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689954.9 → XP_695046.4  calcium release-activated calcium channel protein 1

      UniProtKB/TrEMBL
      A0A0R4IYV8, A0A8N7TF67
      Related
      ENSDARP00000141158.2, ENSDART00000164414.2
      Conserved Domains (1) summary
      pfam07856
      Location:10 → 194
      Orai-1; Mediator of CRAC channel activity
    Nucleotide Protein
    Heading Accession and Version

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