gpc4 glypican 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gpc4provided by ZNC
Official Full Name: glypican 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-011119-1
See related: Ensembl:ENSDARG00000015472 AllianceGenome:ZFIN:ZDB-GENE-011119-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kny; gpc6; gpc4,; gpc4/6; knypek; fc47a08; fe05f10; chunp6920; wu:fc47a08; wu:fe05f10; zgc:194854
Summary: Acts upstream of with a positive effect on lamellipodium organization; regulation of cell migration; and regulation of extracellular matrix assembly. Acts upstream of or within several processes, including gastrulation; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in collagen-containing extracellular matrix; plasma membrane; and side of membrane. Predicted to be active in cell surface and synapse. Is expressed in several structures, including axial chorda mesoderm; blastomere; lateral line system; quadrate-anguloarticular joint; and tail bud. Human ortholog(s) of this gene implicated in Keipert syndrome. Orthologous to human GPC4 (glypican 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (31092327..31151148, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (30752013..30810834, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glypican 4 mediates Wnt transport between germ layers via signaling filopodia.
Title: Glypican 4 mediates Wnt transport between germ layers via signaling filopodia.
Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2.
Title: Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2.
The results suggest that Gpc4 is crucial for generating the environment required for efficient migration of endodermal cells, uncovering a novel function of Gpc4 during development.
Title: Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition.
the chaperon Wls and its ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb and Gpc4.
Title: Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis.
A mutation in glypican4 leads to severe lateral line primordium migration defects. Glypican4 regulates the feedback loop between Wnt/beta-catenin/Fgf signaling in the primordium redundantly with other HSPGs. A mutation in glypican4 affects primordium migration non cell-autonomously
Title: Glypican4 modulates lateral line collective cell migration non cell-autonomously.
disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification.
Title: Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification.
novel mechanism for Wnt5b and Gpc4 regulation of chondrocyte behavior that is independent of the core Wnt/PCP molecules and differs from their collaborative action of controlling cell movements during gastrulation
Title: A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis.
glypican4 mutants do not have decreased proteolysis of ECM substrates, but instead have increased cell surface cadherin protein expression and increased intercellular adhesion.
Title: Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation.
These findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis.
Title: Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

fc47a08 (e-PCR)
- UniSTS:189198

fe48a05.y1 (e-PCR)
- UniSTS:196502

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of cell polarity involved in gastrulation cell migration	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect lamellipodium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect lamellipodium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of extracellular matrix assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within striated muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within striated muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: glypican-4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.