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    srsf5a serine and arginine rich splicing factor 5a [ Danio rerio (zebrafish) ]

    Gene ID: 335396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srsf5aprovided by ZNC
    Official Full Name
    serine and arginine rich splicing factor 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7336
    See related
    Ensembl:ENSDARG00000029818 AllianceGenome:ZFIN:ZDB-GENE-030131-7336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrs5; sfrs5a; fb49e01; zgc:77797; im:6906390; wu:fb49e01; wu:fj09b12
    Summary
    Predicted to enable mRNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system; otic vesicle; pectoral fin; pharyngeal arch; and solid lens vesicle. Orthologous to human SRSF5 (serine and arginine rich splicing factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See srsf5a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36530230..36535067, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36404398..36409318, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene ddb1 and cul4 associated factor 5 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene deubiquitinase DESI2 Neighboring gene synaptojanin 2 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Lawir DF, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571908, Free PMC Article
    2. A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. Balci TB, et al. Br J Haematol, 2014 Oct. PMID 24989799
    3. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
    4. Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes. Hegde A, et al. PLoS One, 2008 Jan 23. PMID 18213387, Free PMC Article
    5. The earliest transcribed zygotic genes are short, newly evolved, and different across species. Heyn P, et al. Cell Rep, 2014 Jan 30. PMID 24440719

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77797

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine and arginine rich splicing factor 5a
    Names
    serine/arginine-rich splicing factor 5a
    splicing factor, arginine/serine-rich 5
    splicing factor, arginine/serine-rich 5a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200867.1 → NP_957161.1  serine and arginine rich splicing factor 5a

      See identical proteins and their annotated locations for NP_957161.1

      Status: PROVISIONAL

      Source sequence(s)
      AY398417
      UniProtKB/TrEMBL
      A0A8M1PBW4, Q6TGT9
      Related
      ENSDARP00000043311.3, ENSDART00000043312.5
      Conserved Domains (2) summary
      cd12337
      Location:5 → 72
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:113 → 184
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      36530230..36535067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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