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    dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 557602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyrk2provided by ZNC
    Official Full Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2804
    See related
    Ensembl:ENSDARG00000094646 AllianceGenome:ZFIN:ZDB-GENE-030131-2804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc18c09; wu:fa09g03; wu:fc18c09; si:ch211-266a5.8
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in central nervous system; myotome; and spinal cord. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dyrk2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13450011..13461599)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13451009..13462742)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene cullin-associated and neddylation-dissociated 1 Neighboring gene si:dkey-39a18.1 Neighboring gene si:ch211-266a5.12 Neighboring gene interferon gamma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis. Sun W, et al. Int J Dev Biol, 2017. PMID 28695966
    2. Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Rodius S, et al. Sci Rep, 2016 May 31. PMID 27241320, Free PMC Article
    3. Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. Morimura R, et al. Dev Neurobiol, 2013 Dec. PMID 23929741
    4. An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Igawa D, et al. Mol Immunol, 2006 Mar. PMID 16005068
    5. Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Tanaka H, et al. Dev Biol, 2012 Oct 15. PMID 22898304

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data indicate that DYRK2 is expressed in the developing muscle progenitor cells in somites and that it positively regulates fast-twitch muscle differentiation, at least at the early stages
      Title: DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis.
    2. These results suggest that the phosphorylation of Dpysl2 and Dpysl3 by Cdk5 and DYRK2 is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.
      Title: Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 2
    NP_001038298.1
    XP_005164697.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044833.2 → NP_001038298.1  dual specificity tyrosine-phosphorylation-regulated kinase 2

      See identical proteins and their annotated locations for NP_001038298.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139631
      UniProtKB/TrEMBL
      A0A2R8QCS7, A0A8M2BC06, A4QP29, Q5RHV3
      Related
      ENSDARP00000122944.1, ENSDART00000145069.2
      Conserved Domains (2) summary
      smart00220
      Location:209 → 522
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:143 → 522
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      13450011..13461599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164640.5 → XP_005164697.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0R4ITS5, A0A2R8QCS7, A0A8M2BBR5, A0A8M2BC06
      Related
      ENSDARP00000140216.1, ENSDART00000172552.2
      Conserved Domains (2) summary
      smart00220
      Location:220 → 533
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:154 → 533
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
    Nucleotide Protein Strain
    Heading Accession and Version

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