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    dio1 iodothyronine deiodinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 799937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dio1provided by ZNC
    Official Full Name
    iodothyronine deiodinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030328-41
    See related
    Ensembl:ENSDARG00000042112 AllianceGenome:ZFIN:ZDB-GENE-030328-41
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Deio1; cb685; zgc:92323
    Summary
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
    Orthologs
    human mouse all
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    Genomic context

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    See dio1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18039559..18042062, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18003847..18006350, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 11b Neighboring gene single stranded DNA binding protein 3b Neighboring gene zinc finger protein GLIS1 Neighboring gene ribosomal protein S8b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction. Bagci E, et al. PLoS One, 2015. PMID 25855985, Free PMC Article
    2. The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). Chen X, et al. Gen Comp Endocrinol, 2019 Jan 15. PMID 30408483
    3. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Dong W, et al. Aquat Toxicol, 2013 May 15. PMID 23531416, Free PMC Article
    4. Parental exposure to cadmium chloride causes developmental toxicity and thyroid endocrine disruption in zebrafish offspring. Tian J, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2020 Aug. PMID 32339758
    5. Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio). Walpita CN, et al. Gen Comp Endocrinol, 2010 Mar 1. PMID 19800339

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the activities of iodothyronine deiodinase type (ID1) and iodothyronine deiodinase type (ID2) showed initially decreased and then increased trend, while the activity of iodothyronine deiodinase type (ID3) significantly decreased during microcystin -LR exposure.
      Title: Waterborne exposure to microcystin-LR alters thyroid hormone levels, iodothyronine deiodinase activities, and gene transcriptions in juvenile zebrafish (Danio rerio).
    2. Knockdown of D1+D2 (D1D2MO) and knockdown of D3 (D3MO) both resulted in transcriptional regulation of energy metabolism and (muscle) development in abdomen and tail
      Title: Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction.
    3. This study investigated deiodinase 1 (Dio1), deiodinase 2 (Dio2), and deiodinase 3 (Dio3) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
      Title: Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages.
    4. role in zebrafish embryonic development
      Title: Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC92323, MGC174383

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thyroxine 5'-deiodinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of neural retina development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type I iodothyronine deiodinase
    Names
    deiodinase, iodothyronine, type I
    NP_001007284.3
    NP_001311333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007283.2 → NP_001007284.3  type I iodothyronine deiodinase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      BC155742, CD606655, CK864452, CO929563, CR847832, DN772220, EE331695, EH492365
      UniProtKB/TrEMBL
      A0A8M1N345, A9JRP6
      Related
      ENSDARP00000121555.1, ENSDART00000132596.2

    2. NM_001324404.1 → NP_001311333.1  type I iodothyronine deiodinase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2) is longer, with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AY221259, BC155742, CD606655, CO929563, CR847832, DN772220, EE331695, EH492365
      UniProtKB/TrEMBL
      A0A8M1P8S9, Q802F6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      18039559..18042062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials