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    cs citrate synthase [ Danio rerio (zebrafish) ]

    Gene ID: 322339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csprovided by ZNC
    Official Full Name
    citrate synthaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1058
    See related
    Ensembl:ENSDARG00000103364 AllianceGenome:ZFIN:ZDB-GENE-030131-1058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55507; wu:fb58e04
    Summary
    Predicted to enable citrate (Si)-synthase activity and identical protein binding activity. Acts upstream of or within response to activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in brain; gill; heart; and muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (33907899..33928316)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (33981368..34001785)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene Rac GTPase activating protein 1 Neighboring gene inactive dipeptidyl peptidase 10 Neighboring gene si:ch211-148l7.4 Neighboring gene coenzyme Q10A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The metabolic regulator PGC-1α directly controls the expression of the hypothalamic neuropeptide oxytocin. Blechman J, et al. J Neurosci, 2011 Oct 19. PMID 22016516, Free PMC Article
    2. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
    3. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Almeida DV, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24055561
    4. Differential mitochondrial dysregulation by exposure to individual organochlorine pesticides (OCPs) and their mixture in zebrafish embryos. Lee H, et al. Environ Pollut, 2021 May 15. PMID 33714130
    5. Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio). Hasumura T, et al. J Comp Physiol B, 2016 Jul. PMID 26951149

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate (Si)-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables citrate (Si)-synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    citrate synthase, mitochondrial
    Names
    citrate (Si)-synthase
    NP_955892.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199598.1 → NP_955892.1  citrate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_955892.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045362
      UniProtKB/Swiss-Prot
      Q7ZVY5
      UniProtKB/TrEMBL
      B2GT34
      Related
      ENSDARP00000135698.1, ENSDART00000159445.2
      Conserved Domains (2) summary
      cd06105
      Location:35 → 462
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:7 → 456
      PLN02456; citrate synthase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      33907899..33928316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVY5.1 GenPept UniProtKB/Swiss-Prot:Q7ZVY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.