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    pgam5 PGAM family member 5, serine/threonine protein phosphatase, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 492357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgam5provided by ZNC
    Official Full Name
    PGAM family member 5, serine/threonine protein phosphatase, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-683
    See related
    Ensembl:ENSDARG00000035608 AllianceGenome:ZFIN:ZDB-GENE-030131-683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb39f09; zgc:92057; wu:fb39f09; wu:fj34f06; zgc:112041; si:dkey-69p22.1
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of mitochondrial fission. Predicted to act upstream of or within programmed cell death. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pgam5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (18925318..18936235)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (18421526..18432443)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene bri3 binding protein Neighboring gene polymerase (DNA directed) iota Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene golgin A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effect of the immobilized microcystin-LR-degrading enzyme MlrA on nodularin degradation and its immunotoxicity study. Wu X, et al. Environ Pollut, 2020 Mar. PMID 31801670
    2. Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport. Roca FJ, et al. Science, 2022 Jun 24. PMID 35737799, Free PMC Article
    3. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Roca FJ, et al. Cell, 2013 Apr 25. PMID 23582643, Free PMC Article
    4. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Roca FJ, et al. Cell, 2019 Sep 5. PMID 31474371, Free PMC Article
    5. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase PGAM5, mitochondrial
    Names
    phosphoglycerate mutase family member 5
    NP_001007324.2
    XP_005165134.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007323.2 → NP_001007324.2  serine/threonine-protein phosphatase PGAM5, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001007324.2

      Status: VALIDATED

      Source sequence(s)
      BC085627, CR388061, EB854230
      UniProtKB/Swiss-Prot
      A2CEB1, Q502L2, Q5U3B2
      Related
      ENSDARP00000051620.5, ENSDART00000051621.6
      Conserved Domains (1) summary
      cd07067
      Location:99 → 272
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      18925318..18936235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165077.4 → XP_005165134.1  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC90
      Conserved Domains (1) summary
      cd07067
      Location:99 → 271
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q502L2.2 GenPept UniProtKB/Swiss-Prot:Q502L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.