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    plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 565914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plekhh1provided by ZNC
    Official Full Name
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061219-1
    See related
    Ensembl:ENSDARG00000053835 AllianceGenome:ZFIN:ZDB-GENE-061219-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    max1; im:6897489; im:7143671
    Summary
    Acts upstream of or within branching involved in blood vessel morphogenesis. Predicted to be located in cytoskeleton. Is expressed in several structures, including digestive system; hindbrain neural plate; nervous system; pectoral fin bud; and trunk. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plekhh1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (37932738..38021592)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (37985153..38074007)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 36, C3H type-like 1a Neighboring gene uncharacterized LOC103909058 Neighboring gene solute carrier family 25 member 21 Neighboring gene paired box 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma. Nagel S, et al. Leuk Lymphoma, 2014 Aug. PMID 24237447
    2. Vertebrate MAX-1 is required for vascular patterning in zebrafish. Zhong H, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17065323, Free PMC Article
    3. A minimally invasive fin scratching protocol for fast genotyping and early selection of zebrafish embryos. Venditti M, et al. Sci Rep, 2022 Dec 30. PMID 36585409, Free PMC Article
    4. Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1. Huang TC, et al. Fish Shellfish Immunol, 2013 Feb. PMID 23261508
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family H member 1
    Names
    PH domain-containing family H member 1
    max-1
    pleckstrin homology domain containing, family H, member 1
    protein max-1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077519.2 → NP_001070987.1  pleckstrin homology domain-containing family H member 1

      See identical proteins and their annotated locations for NP_001070987.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ501275
      UniProtKB/Swiss-Prot
      Q00IB7
      Related
      ENSDARP00000070420.4, ENSDART00000075941.5
      Conserved Domains (9) summary
      smart00139
      Location:896 → 1050
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:755 → 854
      PH; Pleckstrin homology domain
      smart00295
      Location:1063 → 1293
      B41; Band 4.1 homologues
      cd13206
      Location:1289 → 1390
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:646 → 741
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:644 → 737
      PH; PH domain
      pfam00373
      Location:1168 → 1293
      FERM_M; FERM central domain
      cd16269
      Location:145 → 156
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:47 → 156
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      37932738..38021592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00IB7.1 GenPept UniProtKB/Swiss-Prot:Q00IB7

    Gene LinkOut

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